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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
(eLife Sciences Publications, Ltd., 2018-11-09)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness ...
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
(Springer Science and Business Media LLC, 2019-02-25)
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders 1–5 , but neomorphic ...
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
(Public Library of Science (PLoS), 2019-09-20)
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the ...
Framework for rational donor selection in fecal microbiota transplant clinical trials
(Public Library of Science (PLoS), 2019-10-10)
Early clinical successes are driving enthusiasm for fecal microbiota transplantation (FMT), the transfer of healthy gut bacteria through whole stool, as emerging research is linking the microbiome to many different diseases. ...
The Univariate Flagging Algorithm (UFA): An interpretable approach for predictive modeling
(Public Library of Science (PLoS), 2019-10-11)
In many data classification problems, a number of methods will give similar accuracy. However, when working with people who are not experts in data science such as doctors, lawyers, and judges among others, finding ...
Spatial optimization for radiation therapy of brain tumours
(Public Library of Science (PLoS), 2019-06-28)
Glioblastomas are the most common primary brain tumours. They are known for their highly aggressive growth and invasion, leading to short survival times. Treatments for glioblastomas commonly involve a combination of ...
Can machine learning improve patient selection for cardiac resynchronization therapy?
(Public Library of Science (PLoS), 2019-10-03)
Rationale Multiple clinical trials support the effectiveness of cardiac resynchronization therapy (CRT); however, optimal patient selection remains challenging due to substantial treatment heterogeneity among patients who ...
Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
(Public Library of Science (PLoS), 2019-11-07)
The common marmoset (Callithrix jacchus) is increasingly used as an animal model for biomedical research; however, gastrointestinal diseases causing significant morbidity are endemic in many captive marmoset colonies. ...
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
(eLife Sciences Publications, Ltd, 2018-05-10)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the ...
Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function
(Public Library of Science (PLoS), 2019-05-20)
Background Children with oropharyngeal dysphagia have impaired airway protection mechanisms and are at higher risk for pneumonia and other pulmonary complications. Aspiration of gastric contents is often implicated as a ...