MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Graduate Theses
  • View Item
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Graduate Theses
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

A microvillus based approach to model cell rolling

Author(s)
Bose, Suman
Thumbnail
DownloadFull printable version (550.3Kb)
Other Contributors
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Advisor
Rohit N. Karnik.
Terms of use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582
Metadata
Show full item record
Abstract
Cell rolling is a physiological phenomenon, which allows leukocytes to attach to activated vascular endothelium and reach sites of inflammation. A novel approach to model cell rolling is presented in this thesis. The model incorporates all the aspects known to be important to rolling in a semi-analytical framework making it computationally efficient. Bond kinetics have been used to define microvillus attachment probability which is in turn used to find out the net force on the cell. Deformability is also taken into account by an empirical relation which allows shear modulation of cell-surface contact area. The model showed excellent agreement with experimental results over a wide range of shear stresses. Using the model, the effects of cell deformability and microvillus structure have been studied and its implications discussed. The model was also used to predict rolling of microspheres, which showed reasonable agreement with experiments. Finally, the contribution of different features towards stabilization of rolling was elucidated by simulating different hypothetical cases with contributions from different cellular features.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.
 
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
 
Cataloged from student submitted PDF version of thesis.
 
Includes bibliographical references (p. 45-50).
 
Date issued
2009
URI
http://hdl.handle.net/1721.1/54881
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Publisher
Massachusetts Institute of Technology
Keywords
Mechanical Engineering.

Collections
  • Graduate Theses

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.