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Validation and refinement of gene-regulatory pathways on a network of physical interactions

Author(s)
Yeang, Chen-Hsiang, 1969-; Mak, Craig; McCuine, Scott; Workman, Christopher; Ideker, Trey; Jaakkola, Tommi S.; ... Show more Show less
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Abstract
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. Using this procedure, we evaluate 38 candidate regulatory networks in yeast and perform four high-priority gene knockout experiments. The refined networks support previously unknown regulatory mechanisms downstream of SOK2 and SWI4.
Date issued
2005-07
URI
http://hdl.handle.net/1721.1/58915
Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Genome Biology
Publisher
BioMed Central Ltd
Citation
Genome Biology. 2005 Jul 01;6(7):R62
Version: Final published version
ISSN
1474-760X
1465-6914
1465-6906

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