Validation and refinement of gene-regulatory pathways on a network of physical interactions
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gb-2005-6-7-r62.pdf
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Checksum (MD5)
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Author(s)
Yeang, Chen-Hsiang, 1969-
Mak, Craig
McCuine, Scott
Workman, Christopher
Ideker, Trey
Jaakkola, Tommi S.
Date Issued
July 2005
Journal
Genome Biology
Publisher
BioMed Central Ltd
Citation
Genome Biology. 2005 Jul 01;6(7):R62
Version
Final published version
Abstract
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. Using this procedure, we evaluate 38 candidate regulatory networks in yeast and perform four high-priority gene knockout experiments. The refined networks support previously unknown regulatory mechanisms downstream of SOK2 and SWI4.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/gb-2005-6-7-r62
