Log-domain circuit models of chemical reactions
Author(s)Mandal, Soumyajit; Sarpeshkar, Rahul
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We exploit the detailed similarities between electronics and chemistry to develop efficient, scalable bipolar or subthreshold log-domain circuits that are dynamically equivalent to networks of chemical reactions. Our circuits can be used for transient and steady-state simulations, parameter estimations and sensitivity analyses of large-scale biochemical networks. They allow the topology, rate constants, inputs, outputs and initial conditions of the reaction network to be programmed. When reactants are present in low concentrations, random fluctuations in reaction rates become significant; we can also model such stochastic effects. We present experimental results from a proof-of-concept chip implemented in 0.18 mum CMOS technology.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
IEEE International Symposium on Circuits and Systems, 2009. ISCAS 2009
Institute of Electrical and Electronics Engineers
Mandal, S., and R. Sarpeshkar. “Log-domain circuit models of chemical reactions.” Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on. 2009. 2697-2700. ©2009 IEEE.
Final published version
INSPEC Accession Number: 10760474