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Development and optimization of high-throughput zebrafish screening platform

Author(s)
Koo, Bryan Kyo
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Alternative title
Development and optimization of high-throughput vertebrae screening platform
Other Contributors
Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Advisor
Mehmet Fatih Yanik.
Terms of use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582
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Abstract
The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty seconds per fish. This is a two orders of magnitude improvement from the existing manual method, which takes 10 to 15 minutes per fish. The platform also has the ability to rotate the fish in any angle for imaging or laser surgery. There has never been a platform that could align and position a zebrafish consistently and efficiently in such manner before. This crucial functionality was realized through a design in which zebrafish was screened in a capillary tube.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references (p. 67-68).
 
Date issued
2010
URI
http://hdl.handle.net/1721.1/62394
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Publisher
Massachusetts Institute of Technology
Keywords
Electrical Engineering and Computer Science.

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