Manufacturing of Lab-On-a-Chip devices : variation analysis of liquid delivery using blister packs
Author(s)
Selvakumar, Sivesh![Thumbnail](/bitstream/handle/1721.1/62506/712601407-MIT.pdf.jpg?sequence=5&isAllowed=y)
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Alternative title
Manufacturing of LOC devices : variation analysis of liquid delivery using blister packs
Other Contributors
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Advisor
Brian Anthony.
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Components for on-chip storage and delivery of liquid reagent are necessary for many commercial applications of lab-on-a-chip technology. One such system uses a 'blister pack' that is pushed by an actuator. Over the course of product development, Daktari Diagnostics had completed nominal design of a blister pack for their flow rate requirements. This work involved performing a thorough variation analysis of the blister pack to determine the critical sources of variation. For this purpose, the tool of variation simulation modeling (VSM) was used. A numerical model of the blister performance was developed and Monte Carlo simulations were conducted. The results showed that this fluid delivery technique is robust and the number of out-of-specification parts was less than 2%. The critical blister pack parameters that must be controlled were also determined and these can be used to improve process capability.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. Cataloged from PDF version of thesis. Includes bibliographical references (p. [81]-82).
Date issued
2010Department
Massachusetts Institute of Technology. Department of Mechanical EngineeringPublisher
Massachusetts Institute of Technology
Keywords
Mechanical Engineering.