Light scattering of human red blood cells during metabolic remodeling of membrane
Name
Park-2011-Light scattering of human red blood cells during metabolic remodeling of membrane.pdf
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364.03 KB
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Author(s)
Park, YongKeun
Dasari, Ramachandra Rao
Best-Popescu, Catherine A.
Popescu, Gabriel
Date Issued
January 2011
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-optical Instrumentation Engineers
Citation
Park, YongKeun et al. “Light Scattering of Human Red Blood Cells During Metabolic Remodeling of the Membrane.” Journal of Biomedical Optics 16.1 (2011) : 011013. © 2011 Society of Photo-Optical Instrumentation Engineers.
Version
Final published version
Abstract
We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5’-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction phase microscopy together with a Fourier transform light scattering technique. RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Spectroscopy Laboratory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.3524509
