A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells

Author(s)
Du, Pingwu; Lippard, Stephen J.
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Abstract
We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Cd2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels.
Date issued
2010-12
URI
http://hdl.handle.net/1721.1/67683
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Inorganic Chemistry
Publisher
American Chemical Society
Citation
Du, Pingwu, and Stephen J. Lippard. “A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells.” Inorganic Chemistry 49.23 (2010): 10753-10755.
Version: Author's final manuscript
ISSN
0020-1669
1520-510X
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