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dc.contributor.authorHynes, Richard O.
dc.date.accessioned2012-05-04T21:23:09Z
dc.date.available2012-05-04T21:23:09Z
dc.date.issued2012-03
dc.date.submitted2011-09
dc.identifier.issn0021-9525
dc.identifier.issn1540-8140
dc.identifier.urihttp://hdl.handle.net/1721.1/70517
dc.description.abstractThe modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa.en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.language.isoen_US
dc.publisherRockefeller University Press, Theen_US
dc.relation.isversionofhttp://dx.doi.org/10.1083/jcb.201109041en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0 Unporteden_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceRockefeller UPen_US
dc.titleThe evolution of metazoan extracellular matrixen_US
dc.typeArticleen_US
dc.identifier.citationHynes, R. O. “Evolution: The Evolution of Metazoan Extracellular Matrix.” The Journal of Cell Biology 196.6 (2012): 671–679. Web. 4 May 2012.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverHynes, Richard O.
dc.contributor.mitauthorHynes, Richard O.
dc.relation.journalJournal of Cell Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHynes, R. O.en
dc.identifier.orcidhttps://orcid.org/0000-0001-7603-8396
mit.licensePUBLISHER_CCen_US


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