Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study
Author(s)Rosen, Allyson C.; Sugiura, Lisa; Kramer, Joel H.; Gabrieli, Susan; Gabrieli, John D. E.
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A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal of Alzheimer's Disease
Rosen, Allyson C. et al. "Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study." Journal of Alzheimer’s Disease 2011 ; 26(Suppl 3): 349–357.
Author's final manuscript