| dc.contributor.author | Tyers, Mike | |
| dc.contributor.author | Amon, Angelika B | |
| dc.date.accessioned | 2012-05-24T14:37:31Z | |
| dc.date.available | 2012-05-24T14:37:31Z | |
| dc.date.issued | 2009-12 | |
| dc.identifier.issn | 0955-0674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/70918 | |
| dc.description.abstract | Cells must perpetually decide on three big choices in life: to grow, to divide or to die. These
system-level decisions are the output of a complex and still very poorly understood molecular
algorithm, which is built from many different sub-routines. Biochemical and genetic insights,
sometimes coupled with good fortune, have illuminated key individual steps in the networks that
dictate growth, division and death. Increasingly, the complex relationships between these
discrete steps have begun to emerge from the convolved mists of evolutionary construction. A
building ueber-theme is the unexpectedly deep integration of division, growth and death not only with each other, but with cellular metabolism. As covered in this Current Opinion in Cell Biology, this full-on system-wide view of the cell is poised to address both the how and why of big decisions in the life of a cell. | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier Ltd. | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.ceb.2009.10.005 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | Amon via Courtney Crummett | en_US |
| dc.title | Decisions, decisions, decisions | en_US |
| dc.title.alternative | Life and death decisions | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Amon, Angelika, and Mike Tyers. “Life and Death Decisions.” Current Opinion in Cell Biology 21.6 (2009): 767–770. Web. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.approver | Amon, Angelika B. | |
| dc.contributor.mitauthor | Amon, Angelika B. | |
| dc.relation.journal | Current Opinion in Cell Biology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| dspace.orderedauthors | Amon, Angelika; Tyers, Mike | en |
| dc.identifier.orcid | https://orcid.org/0000-0001-9837-0314 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
