| dc.contributor.author | Henderson, Jaclyn L. | |
| dc.contributor.author | McDermott, Sarah M. | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2012-08-14T16:04:11Z | |
| dc.date.available | 2012-08-14T16:04:11Z | |
| dc.date.issued | 2010-09 | |
| dc.date.submitted | 2010-08 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/72118 | |
| dc.description.abstract | Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines. | en_US |
| dc.description.sponsorship | Amgen, Inc. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant number GM-58160) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ol101928m | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Palladium-Catalyzed Amination of Unprotected Halo-7- azaindoles | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Henderson, Jaclyn L., Sarah M. McDermott, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles.” Organic Letters 12.20 (2010): 4438–4441. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Humanities. History Section | en_US |
| dc.contributor.approver | Buchwald, Stephen L. | |
| dc.contributor.mitauthor | Henderson, Jaclyn L. | |
| dc.contributor.mitauthor | McDermott, Sarah M. | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Henderson, Jaclyn L.; McDermott, Sarah M.; Buchwald, Stephen L. | en |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
