Choroidal Thickness in Normal Eyes Measured Using Cirrus HD Optical Coherence Tomography
Author(s)Manjunath, Varsha; Taha, Mohammad; Fujimoto, James G.; Duker, Jay S.
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Purpose: To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). Design: Retrospective, observational case series. Methods: Thirty-four eyes (34 subjects), with no retinal or choroidal disease, underwent high-definition raster scanning using SD-OCT with frame enhancement software. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 2500 μm temporal and nasal to the fovea. The central 1-mm area of the choroid was also measured, along with foveal thickness of the retina. All measurements were performed by 2 independent observers. Statistical analysis was used to correlate inter-observer findings, choroidal thickness and area measurements with age, and choroidal thickness with retinal foveal thickness. Results: The 34 subjects had a mean age of 51.1 years. Reliable measurements of choroidal thickness were obtainable in 74% of eyes examined. Choroidal thickness and area measurements had strong inter-observer correlation (r = 0.92, P < .0001 and r = 0.93, P < .0001 respectively). Area had a moderate negative correlation with age (r = −0.62, P < .0001) that was comparable to the correlation between mean subfoveal choroidal thickness and age (r = −0.61, P < .0001). Retinal and choroidal thickness were found to be poorly correlated (r = −0.23, P = .18). Mean choroidal thickness showed a pattern of thinnest choroid nasally, thickening in the subfoveal region, and then thinning again temporally. Mean subfoveal choroidal thickness was found to be 272 μm (SD, ± 81 μm). Conclusions: Choroidal thickness can be measured using SD-OCT high-definition raster scans in the majority of eyes. Choroidal thickness across the macula demonstrates a thin choroid nasally, thickest subfoveally, and again thinner temporally, and a trend toward decreasing choroidal thickness with age.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
American Journal of Ophthalmology
Manjunath, Varsha et al. “Choroidal Thickness in Normal Eyes Measured Using Cirrus HD Optical Coherence Tomography.” American Journal of Ophthalmology 150.3 (2010): 325–329.e1.
Author's final manuscript