General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A, C and (+)-12,12'- Dideoxychetracin A
Author(s)Kim, Justin; Movassaghi, Mohammad
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A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathiodiketopiperazines.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society
Kim, Justin, and Mohammad Movassaghi. “General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12'-Dideoxychetracin A.” Journal of the American Chemical Society 132.41 (2010): 14376–14378.
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