Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers
Author(s)Maiti, Debabrata; Buchwald, Stephen Leffler
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Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K3PO4 with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of Organic Chemistry
American Chemical Society
Maiti, Debabrata, and Stephen L. Buchwald. “Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers.” The Journal of Organic Chemistry 75.5 (2010): 1791–1794. Web.
Author's final manuscript