Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers

Author(s)
Maiti, Debabrata; Buchwald, Stephen Leffler
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Abstract
Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K3PO4 with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
Date issued
2010-02
URI
http://hdl.handle.net/1721.1/73472
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of Organic Chemistry
Publisher
American Chemical Society
Citation
Maiti, Debabrata, and Stephen L. Buchwald. “Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers.” The Journal of Organic Chemistry 75.5 (2010): 1791–1794. Web.
Version: Author's final manuscript
ISSN
0022-3263
1520-6904
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