Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells

Author(s)
Staerk, Judith; Lyssiotis, Costas A.; Medeiro, Lea A.; Bollong, Michael; Foreman, Ruth K.; ... Show more
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Abstract
Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application.
Date issued
2011-05
URI
http://hdl.handle.net/1721.1/73479
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell (John Wiley & Sons)
Citation
Staerk, Judith et al. “Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells.” Angewandte Chemie International Edition 50.25 (2011): 5734–5736.
Version: Author's final manuscript
ISSN
1433-7851
1521-3773
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