Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells
Author(s)Staerk, Judith; Lyssiotis, Costas A.; Medeiro, Lea A.; Bollong, Michael; Foreman, Ruth K.; Zhu, Shoutian; Garcia, Michael; Gao, Qing; Bouchez, Laure C.; Lairson, Luke L.; Charette, Bradley D.; Supekova, Lubica; Janes, Jeffrey; Brinker, Achim; Cho, Charles Y.; Jaenisch, Rudolf; Schultz, Peter G.; ... Show more Show less
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Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Angewandte Chemie International Edition
Wiley Blackwell (John Wiley & Sons)
Staerk, Judith et al. “Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells.” Angewandte Chemie International Edition 50.25 (2011): 5734–5736.
Author's final manuscript