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Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
(Massachusetts Institute of Technology, 2020)
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture ...
Transmission system overvoltage mitigation through the use of distributed generation (DG) smart inverters
(Massachusetts Institute of Technology, 2020)
The objective of this project is to demonstrate the technical ability and cost-effectiveness of reducing electric transmission system overvoltage violations using distributed generation (DG) smart inverters connected to ...
Assessing sales floor capacity and replenishment strategy
(Massachusetts Institute of Technology, 2020)
Target stores (and the upstream supply chain) have been traditionally designed for a predominantly brick and mortar business, fed by a push supply chain model. With the growing need for omnichannel sales fulαllment, supply ...
Applied discrete event simulation for root cause analysis and evaluation of corrective process change Efficacy within vaccine manufacturing
(Massachusetts Institute of Technology, 2020)
Digital Transformation of the Biopharmaceutical industry is enabling improved operations through smart manufacturing. One area of interest is the application of advanced data analytics techniques to supplement traditional ...
Predictive analysis of installation and operational qualification issues vs. process severity events
(Massachusetts Institute of Technology, 2020)
As the retail industry grows more popular, ABCD, a world-class electronic commerce (e-commerce) business, is increasingly building new Fulfillment Centers (FCs) to support this rapid demand growth. It is integral for ABCD ...