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Evaluation of postponement in the Drug Product supply chain
(Massachusetts Institute of Technology, 2015)
This thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply ...
Reducing reworkable discrepancies through standard work for writing inspection instructions and data distribution
(Massachusetts Institute of Technology, 2013)
Each aircraft on the final assembly line inevitably has minor build errors and deviations from the intended design. Errors, like these, that can be corrected on the line are called reworkable discrepancies. Because hundreds ...
Tool selection and kitting : technical and organizational issues
(Massachusetts Institute of Technology, 2013)
Boeing South Carolina builds the Boeing 787 Dreamliner, the world's first composite-skinned wide-body jet. This new manufacturing facility is evolving to meet the demands of building this complex aircraft. One of the ...
Optimizing procurement and handling costs in a utility
(Massachusetts Institute of Technology, 2014)
We propose a novel method to quantify the cost of activities involved in the picking portion of order fulfillment. We adapt the general method of picking cost quantification to the specific situation of TP&G, a publicly ...
Enhancing the design and procurement of single-use assemblies in biomanufacturing by implementing modular specifications
(Massachusetts Institute of Technology, 2018)
Usage of single-use systems (SUS) in biomanufacturing has expanded rapidly in recent years. Amgen uses SUS at several commercial manufacturing sites, in addition to pilot plants and clinical production. Each single-use ...
Is the pharmaceutical industry ready for value based procurement?
(Massachusetts Institute of Technology, 2012)
In the U.S. news, healthcare related headlines frequent the covers of newspapers and make regular primetime news appearances and the U.S. is not alone. The world is awakening to a need for more equal access to healthcare ...
Improving shop floor visualization and metrics
(Massachusetts Institute of Technology, 2010)
Within the Technical Operations division of Novartis Pharmaceuticals, there is an aggressive vision to be the "Toyota" of the Pharma Industry by 2010. To accomplish this, PharmOps Switzerland has embraced operational ...
Forecasting quality in robotic controller supply chain
(Massachusetts Institute of Technology, 2017)
Between 2017 and 2019, industrial robot installations are estimated to increase by 13% on average per year. As the industrial robot market has grown, so too have customer demands. Many industrial robot manufacturers are ...
R&D project selection : best practices for suppliers
(Massachusetts Institute of Technology, 2010)
Successful research and development is critical in ensuring firms continue to meet customer needs and stay ahead of their competition. Hundreds of billions of dollars are spent every year on these R&D pursuits. It may seem ...
Cost modeling for monoclonal antibody manufacturing
(Massachusetts Institute of Technology, 2011)
The Novartis BioPharmOps division is responsible for manufacturing large molecule products, including monoclonal antibodies, for late stage clinical trials and commercial sales. The BioPharmOps site in Huningue, France is ...