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Now showing items 11-20 of 22
Drug Substance and Drug Product Manufacturing Strategy Assessment for siRNAs
(Massachusetts Institute of Technology, 2021-06)
Amgen currently has its first siRNA program, Asset #1 in phase 2 clinical trials. Until recently, Amgen has been outsourcing the Drug Substance (DS) and Drug Product (DP) manufacturing to external manufacturers, but with ...
Improving inventory management to increase profitability
(Massachusetts Institute of Technology, 2021-06)
ShopSabre, a leading designer and manufacturer of computer numerical control (CNC) routers and plasma tables, is experiencing robust growth, with revenues growing an average of 40% each year since 2015. Due to this growth, ...
Modeling Total Delivered Cost in the Automotive Industry
(Massachusetts Institute of Technology, 2021-06)
Automotive part sourcing is a large scale complex problem that involves the procurement of thousands of individual parts from hundreds of different suppliers. This project focuses on the development of a new Total Delivered ...
High Velocity Supply Chain: Redesigning a Long Lead Time, Short Shelf Life Supply Chain
(Massachusetts Institute of Technology, 2021-06)
Composite materials, which can be simultaneously lighter and stronger than aluminum, provide multiple advantages to the aerospace industry. However, the heat-sensitive resins used in these materials begin degrading as soon ...
Raw Material Optimization to Bend the Biopharmaceutical Cost Curve
(Massachusetts Institute of Technology, 2021-06)
Raw materials sourced from sole third-party suppliers have been identified as one of the key risks to Amgen’s operation. This project aims to reduce raw material costs through sourcing alternative materials and optimizing ...
Increasing e-commerce distribution center capacity through slotting strategy
(Massachusetts Institute of Technology, 2020)
To meet increasing consumer expectations around delivery times, ecommerce retailers must take orders from 'click' to 'ship' as soon as possible. For retailers with tens of thousands of stock keeping units (SKUs), item ...
Inventory modeling for active pharmaceutical ingredient supply chains
(Massachusetts Institute of Technology, 2020)
Pharmaceutical companies traditionally manufactured drugs in-house, and have only recently been increasingly outsourcing production to contract manufacturing organizations (CMOs). In this work, we use inventory modeling ...
Multi echelon supply chain design for Amazon private brands
(Massachusetts Institute of Technology, 2020)
Retailers across the globe continue to grow their private label portfolio to offer customers an alternative to existing brands. Typically, retailers source private label products directly from manufacturers to remove ...
Value of distribution-level reactive power for combined heat and power systems
(Massachusetts Institute of Technology, 2020)
As the U.S. electric grid continues to experience an increase in the penetration of distributed energy resources (DER), electric utilities are evaluating new approaches for utilizing DER to help cost-effectively maintain ...
Artificial intelligence infrastructure into material attributes insights
(Massachusetts Institute of Technology, 2020)
The development of a biopharmaceutical manufacturing process involves an assessment of all possible sources of variation throughout each of the unit operations in the drive toward six sigma manufacturing. The primary goal ...