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Design and operational enhancements for a batch process driven supply chain
(Massachusetts Institute of Technology, 2000)
Film manufacturing at Eastman Kodak involves large-scale batch steps dictated by both technical and economic factors. Large-scale batch processes can lead to an unresponsive and wasteful supply chain. This thesis explores ...
Development of a methodology for the rapid implementation of a sustainable lean manufacturing system
(Massachusetts Institute of Technology, 2000)
Increasing awareness of the competitive edge that the Toyota Production System (TPS) has afforded to the Toyota Motor Company has led many U.S. companies to implement a lean production system of th~ir own. However, most ...
Process Intensification of Spodoptera frugiperda (Sf) Cell Growth via Multi-Parallel Bioreactor System
(Massachusetts Institute of Technology, 2020)
The objective of this project is to improve the yield of the fed-batch manufacturing process for the production of Flublok influenza vaccine, which was approved by the FDA in 2018. In short, Spodoptera frugiperda (SF+) ...
Product management framework for the development of automation solutions for biologics drug substance manufacturing
(Massachusetts Institute of Technology, 2020)
This thesis presents a product management framework for the development of innovative manufacturing automation solutions, and the application of this framework to the development of automation for a continuous biomanufacturing ...
Data-driven predictive modeling for cell line selection in biopharmaceutical production
(Massachusetts Institute of Technology, 2019)
A critical component of the biopharmaceutical development cycle is the selection of the cell line that will become the Master Cell Bank for product manufacturing for clinical and commercial use. This cell line selection ...
An equipment selection methodology for continuous manufacturing of small-molecule drugs
(Massachusetts Institute of Technology, 2019)
Flexible, modular, continuous manufacturing small-scale plants (MCSPs) for small-molecule drugs have been recognized as potential safe and economical solutions for pharmaceutical manufacturing. However, among the variety ...
Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development
(Massachusetts Institute of Technology, 2020)
A critical early step in the development of a new biopharmaceutical is the selection of the master cell bank. Per FDA requirements, the same master cell bank must be used for all toxicity and clinical trials, as well as ...
The use of strategic inventory and packaging postponement to address daily demand variability and seasonal demand patterns in a demand flow environment
(Massachusetts Institute of Technology, 2000)
This LFM thesis describes how Eastman Kodak Company (Kodak) used a strategic buffer of in process inventory and delayed final packaging of end-items to address two issues that surfaced after a recent implementation of a ...
Evaluation wastewater treatment technologies at Ford Powertrain
(Massachusetts Institute of Technology, 2000)
In preparation for an upcoming EPA proposal regarding Free Oil & Grease (FOG) and metal ion content in wastewater effluent, a study was performed for Ford Motor Company that assesses various seconctary wastewater treatment ...
Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
(Massachusetts Institute of Technology, 2005)
A primary bottleneck in DNA-sequencing operations is the capacity of the detection process. Although today's capillary electrophoresis DNA sequencers are faster, more sensitive, and more reliable than their precursors, ...