Browsing MIT Theses by Title
Now showing items 27526-27545 of 61670
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Identification of conserved chromatin-regulatory complexes among the class B synthetic multivulva proteins
(Massachusetts Institute of Technology, 2006)The class A, B, and C synthetic Multivulva (synMuv) genes act redundantly to antagonize Ras-mediated vulval induction in C. elegans. Many of these genes encode proteins that are likely to function in transcriptional ... -
Identification of critical locations across multiple infrastructures for terrorist actions
(Massachusetts Institute of Technology, 2005)This paper discusses a possible approach to ranking geographic regions that can influence multiple infrastructures. Once ranked, decision makers can determine whether these regions are critical locations based on their ... -
Identification of design requirements for a high-performance, low-cost, passive prosthetic knee through user analysis and dynamic simulation
(Massachusetts Institute of Technology, 2013)In January 2012, a partnership was initiated between the Massachusetts Institute of Technology and Bhagwan Mahaveer Viklang Sahayata Samiti (BMVSS, a.k.a., Jaipur Foot) to design a high-performance, low-cost, passive ... -
Identification of DNA polymorphisms
(Massachusetts Institute of Technology, 1982) -
Identification of electrolytic cell parameters using a self-tuning predictor.
(Massachusetts Institute of Technology, 1978) -
Identification of factors responsible for successes or failures in the supply chain based on real-world case studies
(Massachusetts Institute of Technology, 2007)The decision of firms from industrialized nations to outsource part or all of their supply chain activities to offshore countries, like in China, carries with it two major issues. The first is related to the costs and ... -
Identification of features contributing to binding promiscuity of small-molecule inhibitors for rapidly mutating targets
(Massachusetts Institute of Technology, 2017)HIV infection has become a persistent worldwide epidemic despite the continuous development of novel inhibitors. A key challenge in combating HIV and other pandemic viral infections is the ability of the virus to mutate ... -
The identification of gaps and overlaps in the product portfolio
(Massachusetts Institute of Technology, 1999)In product development organizations, the front end of product development is usually confined to planning within business units for product families and individual products. This can pose a problem for businesses, as ... -
Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
(Massachusetts Institute of Technology, 2019)Lung adenocarcinoma (LUAD) remains the world's leading cause of cancer related mortality with an estimated two-hundred thousand new cases arising in 2019 in the United states alone. Molecular characterization of patient ... -
Identification of good practices in the operation of nuclear power plants
(Massachusetts Institute of Technology, 2005)This work developed an approach to diagnose problems and identify good practices in the operation of nuclear power plants using the system dynamics technique. The research began with construction of the ORSIM (Nuclear Power ... -
Identification of hazards in chemical process systems
(Massachusetts Institute of Technology, 1991) -
Identification of HIV protease mutants with improved specificities toward an Alzheimer's Disease associated peptide sequence
(Massachusetts Institute of Technology, 2006)We have developed the first protease specificity engineering technology intended to serve as a general-purpose source of target-specific protease mutants with potential therapeutic applications. We used this E. coli-based ... -
Identification of leading indicators for producibility risk in early-stage aerospace product development
(Massachusetts Institute of Technology, 2015)Producibility is an emergent property of product development and manufacturing systems that encapsulates quality, product compliance, cost, and schedule. Detailed product definition and process variation have traditionally ... -
Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX
(Massachusetts Institute of Technology, 2015)Malaria kills over 500,000 people annually, the majority of whom are children under five years old in sub-Saharan Africa. This disease is caused by several parasite species, of which Plasmodium falciparum is associated ... -
The identification of natural dyes in pre-Columbian Andean textiles by mass spectrometry.
(Massachusetts Institute of Technology, 1977) -
Identification of new functions for BRCT domains
(Massachusetts Institute of Technology, 2008)Our lab identified the tandem BRCT domains of PTIP function as a DNA damage responsive phospho binding domain that recognizes proteins phosphorylated by ATM and ATR after DNA damage. The PTIP tandem BRCT domains are ... -
Identification of new genes and pathways that act to delay C. elegans aging
(Massachusetts Institute of Technology, 2008)Aging of an organism is determined by both stochastic and genetic components. The importance of genes is illustrated by the discovery of single gene mutations that alter lifespans of species ranging from invertebrates C. ... -
Identification of novel branch points reveals insights into RNA processing
(Massachusetts Institute of Technology, 2015)Pre-mRNA splicing is a ubiquitous process necessary for the production of functional eukaryotic mRNAs. The branch point (BP) sequence is one of three key nucleotide sequences required for pre-mRNA splicing, however, in ... -
Identification of novel genes regulated by innervation and characterization of subsynaptic proteins in skeletal muscle
(Massachusetts Institute of Technology, 1997) -
Identification of novel proteins that regulate the amino acid-sensitive mTORC1 pathway
(Massachusetts Institute of Technology, 2016)mTOR is a serine-threonine kinase that, as the catalytic subunit of mTORC1, promotes growth and anabolism. Due to its central role in metabolism, the local and systemic environment surrounding the cell tightly regulate ...
