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Modeling and analysis of single-molecule experiments
(Massachusetts Institute of Technology, 2005)
Single molecule experiments offer a unique window into the molecular world. This window allows us to distinguish the behaviors of individual molecules from the behavior of bulk by observing rare events and heterogeneity ...
Two-dimensional polymer synthesis : towards a two-dimensional replicating system for nanostructures
(Massachusetts Institute of Technology, 2005)
The general concept of a replicating monolayer system is introduced as a new method of nanostructure synthesis. One possible implementation of a 2-D replicating system is pursued which uses a diacetylene moiety for ...
Polaritonics : an intermediate regime between electronics and photonics
(Massachusetts Institute of Technology, 2005)
This thesis contains the foundational work behind the field of polaritonics. Corresponding to a frequency range from roughly 100 gigahertz up to 10 terahertz, polaritonics bridges the gap between electronics and photonics. ...
Laboratory measurements and modeling of trace atmospheric species
(Massachusetts Institute of Technology, 2005)
Trace species play a major role in many physical and chemical processes in the atmosphere. Improving our understanding of the impact of each species requires a combination of laboratory exper- imentation, field measurements, ...
Poly(phenylene ethynylene)s in biosensor applications
(Massachusetts Institute of Technology, 2005)
Conjugated polymers have shown remarkable sensitivity for the detection of a variety of analytes, ranging from explosives to biological molecules such as DNA. This thesis presents three new applications of poly(phenylene ...
Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
(Massachusetts Institute of Technology, 2005)
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Saccharomyces cerevisiae RNR is a class I RNR composed of a dimeric large subunit (RI), containing the active site and ...
Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics
(Massachusetts Institute of Technology, 2005)
The purpose of this thesis is to explore the conjugation of biomolecules to platinum(IV) compounds. Ever since the serendipitous discovery that cisplatin has cytotoxic properties in the 1970's, research has focused on both ...
Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
(Massachusetts Institute of Technology, 2005)
The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This ...
Inhibition of Hsp90 in Streptomyces coelicolor
(Massachusetts Institute of Technology, 2005)
Inhibition of the chaperone protein Hsp90 in plants and insects has been found to result in drastic changes in phenotype. We investigated the effect of Hsp90 inhibition on the bacteria Streptomyces coelicolor. These changes ...
Design and synthesis of novel functionalized sensors for the biological imaging of zinc(II) and nitric oxide
(Massachusetts Institute of Technology, 2005)
CHAPTER 1: Fluorescent Sensors for the Biological sensing of Zinc(II) A variety of fluorescent techniques have been developed for the in vivo sensing of Zn2+. This chapter presents a brief overview of techniques used to ...