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Predictive Modeling and Optimization of Autoinjector Manufacturing
(Massachusetts Institute of Technology, 2021-06)
The manufacture of drug delivery devices requires the assembly of multiple device components with the corresponding drug products, often with an abundance of data being collected at each assembly stage. This data represents ...
An Analytical Approach to Inventory Management for Telecommunications Network Equipment
(Massachusetts Institute of Technology, 2021-06)
Verizon’s core network relies on routers that use expensive plug-in cards (PICs) to function. PIC failures can cause disruptions to FiOS or wireless service in the surrounding area. Maintaining an appropriate level of spare ...
Applying Lean Manufacturing Concepts to a High-Mix Low-Volume Make to Order Environment
(Massachusetts Institute of Technology, 2021-06)
Despite research documenting the operational benefits achieved by reducing the number of product offerings, manufacturing businesses frequently serve markets in which customers demand a large variety of products with options ...
Effective Integration of Additive Manufacturing at a Large Manufacturing Company
(Massachusetts Institute of Technology, 2021-06)
Additive manufacturing (AM) has the potential to create significant value at large manufacturing companies such as Corning, but to date adoption has been slow. Corning invested in AM early, establishing a central AM team ...
Determining Optimal Supply Level for Intermittent and Low Demand Parts
(Massachusetts Institute of Technology, 2021-06)
One of the challenges in the heavy equipment aftermarket business is determining what optimal level of supply looks like for intermittent and low demand parts. For these parts, it is difficult to forecast the needed demand ...
Creating Optimized Value Creation Conditions: An Additive Manufacturing Model
(Massachusetts Institute of Technology, 2021-06)
Stryker's additive manufacturing (AM) business unit has pioneered cost competitive Metal AM capabilities at scale. Recently the company has been exploring the possibility of expanding AM capabilities into other materials, ...
Network and Workflow Design and Standardization in a Large Distribution Center
(Massachusetts Institute of Technology, 2021-06)
The retail industry is experiencing exploding growth in the digital segment and a shift in consumer delivery expectations. While distribution networks and the individual facilities were constructed to fulfill demand for ...
Assessment of Virtual-Reality-Based Digital Twins in Automotive Manufacturing Process Validation
(Massachusetts Institute of Technology, 2021-06)
This research analyzes the usage of the digital twin technology, IC.IDO, in the automotive new model launch cycle by assessing the tool's capability to identify issues in the digital design period, prior to testing in the ...
Designing a Make vs. Buy Strategy for Expendable and Attritable Aircraft Engine Development
(Massachusetts Institute of Technology, 2021-06)
Military aircraft engine customers are increasingly demanding agility and affordability for both engine development and production. In this thesis, we propose that this inflection point in aerospace and defense towards ...
Applications of Machine Learning and First-Principle Modeling to Evaluate Design Enhancements in Autoinjectors
(Massachusetts Institute of Technology, 2021-06)
One of the key guiding principles in Amgen operations is to ensure reliability of the offered combination products to best serve patients and maintain a competitive advantage for the business. With a broad device portfolio ...