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Now showing items 161-170 of 170
Enhancing the design and procurement of single-use assemblies in biomanufacturing by implementing modular specifications
(Massachusetts Institute of Technology, 2018)
Usage of single-use systems (SUS) in biomanufacturing has expanded rapidly in recent years. Amgen uses SUS at several commercial manufacturing sites, in addition to pilot plants and clinical production. Each single-use ...
Evaluation of predictive computational modelling in biologic formulation development
(Massachusetts Institute of Technology, 2017)
Computational modelling has completely redefined the experimentation process in many industries, allowing large sets of design concepts to be tested quickly and cheaply very early in the innovation process. Harnessing the ...
Deep learning for automated visual inspection of uncured rubber
(Massachusetts Institute of Technology, 2018)
This thesis proposes a data-driven approach to automate the visual inspection of uncured rubber tire assemblies. Images collected from a machine vision system are used to develop proof of concept predictive models to ...
Integrating additive manufacturing into operations at middle market companies
(Massachusetts Institute of Technology, 2019)
Ascent Aerospace's leadership recognizes the transformative potential of additive manufacturing (AM) to the aerospace tooling industry. As a middle market company, Ascent required a deliberate approach to identifying areas ...
Application of risk management frameworks to medical device production development
(Massachusetts Institute of Technology, 2019)
Effective risk management is critical when manufacturing medical products to avoid any potential impact to patients due to supply disruptions or quality excursions. As Flex LTD, an end-to-end manufacturing solutions provider, ...
Predictive earthquake damage modeling for natural gas distribution infrastructure
(Massachusetts Institute of Technology, 2018)
The Pacific Gas and Electric Company (PG&E) operates and maintains 48,000 miles of natural gas pipeline, serving over 4.3 million customer accounts. Along with water, electric power, and transportation services, these ...
Oral drug delivery as an alternative to needle-based injection for large molecules : an assessment of the field & evaluation of high-priority technologies
(Massachusetts Institute of Technology, 2018)
Oral delivery of large molecules is widely considered the "holy grail" of drug delivery, but attempts to achieve this within the past century have been met with a lack of success, confounded by low bioavailability. Novel ...
Environmental sustainability assessment tool for factories
(Massachusetts Institute of Technology, 2016)
General interest and international regulations have begun to create a world in which consumers demand to know how their products are made and companies must provide that transparency. With over 15,000 suppliers, Li & Fung ...
Virtual pooling approximation using longest path network optimization
(Massachusetts Institute of Technology, 2018)
Abstract This thesis proposes a network swapping mechanism to approximate a virtual finished goods inventory pool under the constraint of fragmented commercial channel ownership. Globally, Caterpillar sells its product ...
Container removal and replacement automation : design and development of robotic work cells for warehouse automation
(Massachusetts Institute of Technology, 2019)
Amazon has grown at a rapid pace. In 2018, Amazon retail sales amounted to $141.92B, up 19.7% from the previous year. The number of units shipped through its Prime program alone grew by 20% from 5 billion the previous year ...