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In vivo research scheduling and coordination in the pharmaceutical industry
(Massachusetts Institute of Technology, 2008)
(cont.) A multi-criteria objective function uses the researcher's preference to optimize both room assignments and procedure start time. A Tabu search meta-heuristic has been developed to generate a near-optimal solution. ...
Analysis of email and phone queuing systems in a world-wide contact center network
(Massachusetts Institute of Technology, 2008)
Contact centers are operated by companies to answer customer inquiries via phone calls or email. Customers often equate the service they are provided while interacting with a contact center to the quality of a company's ...
Achieving business and operational excellence in the pharmaceutical industry
(Massachusetts Institute of Technology, 2008)
Historically the pharmaceutical industry has been highly profitable. However, the increasing regulatory requirements, bargaining power of buyers, and drug failures together with the threat of biosimilars and decreasing R&D ...
The enterprise architecting framework applied to the supply organization of a sourcing management center of excellence
(Massachusetts Institute of Technology, 2008)
The basis to develop this thesis was performed after executing an internship in ABB Inc. The main objective of the study was to design the organization to operate the procurement function at a new manufacturing campus.The ...
Enabling manufacturing flexibility issue resolution in advanced vehicle development
(Massachusetts Institute of Technology, 2008)
Manufacturing Flexibility is a broad term used to describe a metric that can be measured in many different ways. Current industry experts agree that Flexibility is one of the key measures that will help the automotive ...
Cycle time reduction through wafer starts control
(Massachusetts Institute of Technology, 2008)
Intel's Fab 17, located in Hudson, Massachusetts, has experienced dramatic improvements in its cycle time performance in the last two years. These improvements have been attributed to lean implementation efforts, reduced ...
Evaluating cost-reduction alternatives and low-cost sourcing opportunities for aerospace castings and forgings
(Massachusetts Institute of Technology, 2008)
As companies continue to outsource large portions of their manufacturing, managing costs in the supply chain is increasingly important in reducing overall costs and remaining competitive. Low-cost sourcing has become an ...
Using Virtual Business Systems to drive lean behavior in engineering design and support
(Massachusetts Institute of Technology, 2008)
Virtual Business System (VBS) is a visual-based analytics and real-time information displaying system. It first started at Raytheon's Andover manufacturing facility in early 2000 with the strategic objectives of linking ...
Implementation of the new FDA quality by design guidance in pharmaceutical production
(Massachusetts Institute of Technology, 2008)
Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
Lean transformation methodology and implementation in biopharmaceutical operations
(Massachusetts Institute of Technology, 2008)
Amgen's Operations division is responsible for the production, release and distribution of commercial and clinical products. Due to industry consolidation, impending competition and revenue impacts, Amgen is facing the ...