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Now showing items 21-30 of 89
Distribution and replenishment optimization between locations of high and low real estate cost
(Massachusetts Institute of Technology, 2020)
As companies expand and innovate, it is sometimes prudent to be conservative when incorporating new products and technologies. Instead of constructing buildings to store new products, firms may look to optimize re-allocation ...
Impact of part proliferation on a high mix low volume manufacturing environment
(Massachusetts Institute of Technology, 2020)
This project set out to create a framework for conducting a cost benefit analysis of part proliferation looking into first, second and third order effects of part specialization within the entire Caterpillar enterprise. ...
Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
(Massachusetts Institute of Technology, 2020)
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture ...
Evaluation of automated storage and retrieval in a distribution center
(Massachusetts Institute of Technology, 2020)
In the face of e-commerce growth and rising customer delivery expectations, companies must adapt to meet shorter contract shipping requirements with existing infrastructures. The "Amazon effect", an evolution resulting in ...
Reducing variations in a highly constrained environment in order to increase production capacity
(Massachusetts Institute of Technology, 2020)
Variations and the negatives effects it causes on production capacity and planning are topics of significant interest in the manufacturing communities. This research investigates the hypothesis that, when operating in a ...
Developing a robust harvest for high cell density CHO cell culture
(Massachusetts Institute of Technology, 2020)
Ship-pack replenishment optimization in a two-echelon distribution system with lost sales and seasonal product obsolescence
(Massachusetts Institute of Technology, 2021-06)
As a retailer attempts to leverage a two-echelon distribution system to forward-deploy inventory, a number of cost elements must be considered when deciding the quantity of a given SKU to replenish to the forward-deployed ...
Breaking the Mold on Job Shops
(Massachusetts Institute of Technology, 2021-06)
Job shops lack disciplined manufacturing strategy and execution. High variation of work results in high levels of WIP, unbalanced loads, poor shop floor visibility, underutilized machinery, and ultimately poor on time ...
Implementation Roadmap and Real Options Analysis for Biopharmaceutical Technology Introduction
(Massachusetts Institute of Technology, 2021-06)
Biologics manufacturing is complex involving several unit operations for drug production. As the industry moves forward, new technologies are introduced to decrease cycle time, reduce costs, and improve quality for these ...
Creating Good Jobs in Automotive Manufacturing
(Massachusetts Institute of Technology, 2021-06)
A stable workforce is critical to successful manufacturing operations. A stable workforce results in repeatability of jobs, which in turn leads to higher quality vehicles and decreased down-time on the assembly line. It ...