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Now showing items 21-30 of 47
New approach to drug product process design : leveraging first principles modeling and cross-product process monitoring to improve process design robustness
(Massachusetts Institute of Technology, 2015)
Abstract The vision of the Operations Technology Group at Amgen is to enable a robust pipeline through focused and efficient operations research studies. Process design is traditionally developed by performing experiments, ...
Process and system variation impacts on 777 wings manufacturing
(Massachusetts Institute of Technology, 2015)
The Boeing 777 has seen an increased the rate of production from one plane every 7 days to one plane every 2.5 days. Wing production has relied on a sizeable work force and the use of overtime to meet this demand. The ...
Application of multiple information sources to prediction of engine time on-wing
(Massachusetts Institute of Technology, 2015)
The maintenance and operation of commercial turbofan engines relies upon an understanding of the factors which contribute to engine degradation from the operational mission, environment and maintenance procedures. A multiple ...
A management science approach for developing a decision model for portfolio rationalization of consumer personal computers
(Massachusetts Institute of Technology, 2015)
Commoditization of the PC market has led to a shift in strategy at Dell away from customization towards defining specific consumer configurations ahead of time. This shift creates new planning and decision processes around ...
Reducing intraday patient wait times through just-in-time bed assignment
(Massachusetts Institute of Technology, 2015)
Massachusetts General Hospital (MGH) is the oldest and largest hospital in New England as well as the original and largest teaching hospital of the Harvard Medical School. The neuroscience units experience patient flow ...
MGH Internal Medicine Associates : primary care redesign
(Massachusetts Institute of Technology, 2015)
Internal Medicine Associates (IMA) is the largest primary care practice at Massachusetts General Hospital (MGH) with over 40 attending physicians, 60 residents, and 80 support staff that deliver care to more than 30,000 ...
Practical example of base source optimization : footwear profiling at Nike, Inc.
(Massachusetts Institute of Technology, 2015)
The long term sourcing for footwear development, or "profiling," at Nike, Inc. has grown with the company and become significantly complex. It is no longer possible for a single person, no matter the level of experience, ...
Diagnosing intensive care units and hyperplane cutting for design of optimal production systems
(Massachusetts Institute of Technology, 2015)
This thesis provides a new framework for understanding how conditions, people, and environments of the Intensive Care Unit (ICU) effect the likelihood the preventable harm will happen to a patient in the ICU. Two years of ...
Predicting corrosion on protected buried steel natural gas distribution pipelines
(Massachusetts Institute of Technology, 2015)
PG&E uses cathodic protection, which connects the pipeline to sacrificial anodes that corrode instead of the pipeline, to prevent corrosion on its buried steel natural gas pipelines. However, corrosion leaks still occur. ...
Investigation of integrally-heated tooling and thermal modeling methodologies for the rapid cure of aerospace composites
(Massachusetts Institute of Technology, 2015)
Carbon Fiber Reinforced Polymer (CFRP) composite manufacturing requires the CFRP part on the associated tool to be heated, cured, and cooled via a prescribed thermal profile. Current methods use large fixed structures such ...