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Now showing items 21-30 of 33
Anomaly detection for natural gas regulator stations
(Massachusetts Institute of Technology, 2016)
Natural gas regulator stations control the flow of gas across PG&Es gas transmission and distribution system. Ensuring the proper functioning of these-stations is critical for the safety of the natural gas system. Currently, ...
Wafer defect prediction with statistical machine learning
(Massachusetts Institute of Technology, 2016)
In the semiconductor industry where the technology continues to grow in complexity while also striving to achieve lower manufacturing costs, it is becoming increasingly important to drive cost savings by screening out ...
Application of continuous improvement methodologies and techniques in the Drug Design Cycle
(Massachusetts Institute of Technology, 2016)
Amgen, one of the world's leaders in biotechnology, is currently investing in ways to better serve its patients by providing new drugs sooner, and to ensure its competitiveness for years to come. One way is to increase the ...
Wires-down predictive modeling and preventative measures optimization
(Massachusetts Institute of Technology, 2016)
In 2012, the Pacific Gas and Electric Company (PG&E) identified overhead wires-down failure events as an important metric for safety and reliability. These events occur when power lines contact the ground and are caused ...
Impulse mixer technology reliability and redesign improvement in biotechnology drug substance manufacturing
(Massachusetts Institute of Technology, 2016)
Objective: In place of traditional stainless steel systems, the "Flexible Manufacturing" technology used at Amgen employs the impulse mixer single-use system, a bag technology, to house the product and serve as the locale ...
Evaluating inventory ordering policies : a methodology and application
(Massachusetts Institute of Technology, 2016)
This work considers how inventory ordering policies can distort the demand signal as it moves up the supply chain, magnifying the impact of the bullwhip effect. We define an inventory ordering policy as a set of rules that ...
Size curve optimization for replenishment products
(Massachusetts Institute of Technology, 2016)
Nike replenishment products (make to stock) are forecasted and planned at a style/color level and then disaggregated to a size level forecast through the use of a size curve. This method of forecasting and planning provides ...
Implementing postponement into low-volume/high-variability manufacturing
(Massachusetts Institute of Technology, 2017)
Aircraft Company X (AX) manufactures and assembles an immense variety of parts utilized as drive systems and rotor components across its multiple aircraft. The company's value proposition is maintaining the ability to build ...
Measurement and prediction of inpatient case manager workload in a tertiary hospital setting
(Massachusetts Institute of Technology, 2016)
A patient's care needs often extend past discharge from an acute hospital setting. At Massachusetts General Hospital (MGH), inpatient case managers, acting in a discharge planning capacity, help develop and coordinate the ...
Scheduling a global engine maintenance network
(Massachusetts Institute of Technology, 2016)
This thesis addresses the allocation of gas turbine aircraft engines to maintenance facilities. Scheduling a global engine maintenance network can be very complex and challenging. This project pertains particularly to the ...