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Product management framework for the development of automation solutions for biologics drug substance manufacturing
(Massachusetts Institute of Technology, 2020)
This thesis presents a product management framework for the development of innovative manufacturing automation solutions, and the application of this framework to the development of automation for a continuous biomanufacturing ...
Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
(Massachusetts Institute of Technology, 2005)
The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...
Using design of experiments to improve a batch chemical process
(Massachusetts Institute of Technology, 2010)
Novartis Vaccines and Diagnostics has made a strong commitment to manufacturing seasonal influenza vaccines through their cell culture technology called Optaflu®. The goal of this project is to improve overall process yield ...
The business case for continuous manufacturing of pharmaceuticals
(Massachusetts Institute of Technology, 2010)
Manufacturing in the pharmaceutical industry is presently characterized as a batch production system, which has existed in its current form for decades. This structure is the result of historical regulatory policy as well ...
Strategic development of a manufacturing execution system (MES) for cold chain management using information product mapping
(Massachusetts Institute of Technology, 2011)
The Vaccines & Diagnostics (V&D) division of Novartis recently developed a global automation strategy that highlights the need to implement a manufacturing execution system (MES). Benefits of an MES (electronic production ...
Integrating cost consequences into a high quality manufacturing environment
(Massachusetts Institute of Technology, 2003)
Intel Corporation, the world leader in manufacturing microprocessors, has beer successful in achieving high margins because of its ability to successfully deliver high volume and reliable microprocessors at high demand. ...
A "go to market" strategy : enabling P&G profitable share growth through streamlined logistics
(Massachusetts Institute of Technology, 2002)
The cosmetics industry is an intensely competitive, fashion-driven industry. As such, new product launch processes are viewed to be a competitive advantage in promoting continued brand awareness in the market place. However, ...
Implementation of new technology in a regulated environment
(Massachusetts Institute of Technology, 2004)
This thesis investigates potential improvements to the manufacturing process through the implementation of process analytical technologies (PAT) in the heavily regulated pharmaceutical industry. The thesis focuses on the ...
A comparative analysis of diagnostic tools and techniques for manufacturing business support
(Massachusetts Institute of Technology, 2004)
The overriding objective of diagnostic assessment is change. Assessment processes are a mechanism to identify areas that merit change. In order to maximize the possibility that a company will adopt recommended changes ...
Analysis of variability in the semiconductor industry
(Massachusetts Institute of Technology, 2004)
While the pace of technical innovation in the semiconductor industry continues to accelerate, business processes and supply chain techniques have not kept up. Microprocessor performance improvement continues to follow ...