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Now showing items 31-40 of 41
Optimization of preclinical profiling operations in drug discovery
(Massachusetts Institute of Technology, 2007)
In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...
Developing flexibility in assembly environments
(Massachusetts Institute of Technology, 2007)
Manufacturing flexibility has been a topic of interest for both researchers and practitioners for several decades. Despite the amount of attention that flexibility receives, it remains a nebulous concept to those in industry ...
Lean transformation in aerospace assembly operations
(Massachusetts Institute of Technology, 2007)
For the past two decades, virtually all manufacturing companies in the United States have adopted or are in the process of adopting lean manufacturing. Globalization has resulted in the increased availability of reliable, ...
Optimization of chemical reagent storage and distribution at Novartis Institutes for BioMedical Research
(Massachusetts Institute of Technology, 2007)
The Novartis Institutes for BioMedical Research is the drug discovery arm of Novartis Pharmaceuticals. Drug discovery is generally considered to be the primary driver for success in the pharmaceutical industry. Success in ...
Implementing lean material management in an extended value stream
(Massachusetts Institute of Technology, 2007)
American Axle & Manufacturing, Inc. (AAM) is still in the process of transitioning to a culture of "lean manufacturing" as opposed to the current culture of "mass production". This thesis involved working with AAM employees ...
Decision support systems for tool reuse and EOL processes
(Massachusetts Institute of Technology, 2007)
Intel® is a manufacturing company that concentrates on the fabrication process of computer chips. Over the years and into the future, Intel® has gone through multiple and advanced generations of manufacturing technology ...
Improving maintenance operation through transformational outsourcing
(Massachusetts Institute of Technology, 2007)
Outsourcing maintenance to third-party contractors has become an increasingly popular option for manufacturers to achieve tactical and/or strategic objectives. Though simple in concept, maintenance outsourcing is difficult ...
Effective synchronization of MRP to production during a lean transformation
(Massachusetts Institute of Technology, 2007)
Raytheon - Network Centric Systems (NCS) division develops and produces mission solutions for networking, command and control, battlespace awareness, and air traffic management. The facility in Largo, Florida, produces ...
Fab cycle time improvement through inventory control : a wafer starts approach
(Massachusetts Institute of Technology, 2007)
Intel's Colorado Springs wafer fabrication facility, known internally as F23, has undertaken several initiatives to reduce cycle time including High Precision Maintenance (HPM), content reduction through the application ...
Building flexibility in the volatile aftermarket parts : supply chains of the defense aerospace industry
(Massachusetts Institute of Technology, 2007)
Within the Integrated Defense Systems of The Boeing Company, aftermarket support of military aircraft serves as an increasingly large source of revenue. One of the newest contracts between Boeing and the U.S. Government ...