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Now showing items 31-40 of 51
Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment
(Massachusetts Institute of Technology, 2016)
Gene therapy is a promising modality for the potential treatment of rare Mendelian diseases. To date a number of high profile proof-of-concept studies within the industry have demonstrated the significant disease-correcting ...
Optimization of preclinical profiling operations in drug discovery
(Massachusetts Institute of Technology, 2007)
In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...
Capacity analysis, cycle time optimization, and supply chain strategy in multi-product biopharmaceutical manufacturing operations
(Massachusetts Institute of Technology, 2011)
Application of system optimization theory, supply chain principles, and capacity modeling are increasingly valuable tools for use in pharmaceutical manufacturing facilities. The dynamics of the pharmaceutical industry - ...
Lean transformation methodology and implementation in biopharmaceutical operations
(Massachusetts Institute of Technology, 2008)
Amgen's Operations division is responsible for the production, release and distribution of commercial and clinical products. Due to industry consolidation, impending competition and revenue impacts, Amgen is facing the ...
Implementation of the new FDA quality by design guidance in pharmaceutical production
(Massachusetts Institute of Technology, 2008)
Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
Critical process parameter determination during production start-up
(Massachusetts Institute of Technology, 2004)
Production start-up data is consistently utilized in a reactive manner during the initial stages of a product's lifecycle. However, if proactive information systems are created before full scale production starts, ramp-up ...
Control and optimization of E. coli picking process for DNA sequencing
(Massachusetts Institute of Technology, 2004)
As part of its responsibility to the National Institutes for Health, the sequencing operation at the Broad Institute strives for cost-effective production. This thesis attempts to reduce variability in the sequencing ...
Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
(Massachusetts Institute of Technology, 2005)
A primary bottleneck in DNA-sequencing operations is the capacity of the detection process. Although today's capillary electrophoresis DNA sequencers are faster, more sensitive, and more reliable than their precursors, ...
Development of operations based long range network capacity planning models
(Massachusetts Institute of Technology, 2011)
Planning for vaccines manufacturing capacity is both a complex task requiring many inputs and an important function of manufacturers to ensure the supply of vaccines that prevent life-threatening illnesses. This thesis ...
Mergers and acquisitions process improvement in a matrix organization
(Massachusetts Institute of Technology, 2012)
3M has had aggressive growth through acquisitions. Almost all of the acquisitions add new manufacturing sites to the existing manufacturing and distribution networks. 3M is composed of 38 divisions (as of 2011) with ...