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Understanding and improving the anticancer activity of cisplatin
(Massachusetts Institute of Technology, 2001)
The purpose of this thesis is to further our understanding of the mechanism of action of cis-diamminedichloroplatinum(II) (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, ...
Novel function and regulation of mutagenic DNA polymerases in Escherichia coli
(Massachusetts Institute of Technology, 2007)
The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV-light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
Biological scaffolds for the peptide-directed assembly of nanoscale materials and devices
(Massachusetts Institute of Technology, 2006)
The utilization of biological factors in the design, synthesis and fabrication of nano-scaled materials and devices presents novel, large scale solutions for the realization of future technologies. In particular, we have ...
Gene expression-based screening of inhibitors of signal transduction
(Massachusetts Institute of Technology, 2006)
Advances in our understanding of cellular function and signal transduction have resulted in ever increasing number of therapeutical targets and, consequently, underscored a demand for simple and universally applicable ...
Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
(Massachusetts Institute of Technology, 2008)
Many enzymes and ion channels consist of multiple subunits and/or multiple distinct functional components. Coordinated conformational changes through allosteric interactions between subunits and/or between functional units ...
Studies directed towards the total synthesis of (+)-sieboldine A
(Massachusetts Institute of Technology, 2008)
Progress towards the total synthesis of sieboldine A is described. This synthetic approach uses a nickel-catalyzed alkyne-ketone reductive cyclization to form the hydrindane core of the natural product in good yield and ...
The detection of nitric oxide and its reactivity with transition metal thiolate complexes
(Massachusetts Institute of Technology, 2008)
Nitric oxide (NO) is a molecule that is essential for life and regulates both beneficial and harmful processes. Because this gaseous radical influences many aspects of health and disease, we wish to explore the relationship ...
Polymers containing calix[4]arenes and triptycenes : new syntheses, properties and applications
(Massachusetts Institute of Technology, 2008)
This thesis details the development of new synthetic methods for making polymers with complex molecular structures. Calix[4]arenes and triptycenes are the two major molecular building blocks for constructing the functional ...
Observing the unfolding transition of [beta]-hairpin peptides with nonlinear infrared spectroscopy
(Massachusetts Institute of Technology, 2008)
The biological function of a protein is in large measure determined by its three-dimensional structure. To date, however, the transition of the protein between the native and non-native conformations is not well-understood. ...
Glycocalyx acting as a mechanotransducer of fluid shear stress
(Massachusetts Institute of Technology, 2005)
It is widely recognized that fluid shearing forces acting on endothelial cells (ECs) have a profound effect on EC morphology, structure and function. Recent investigations in vivo have indicated the presence of a thick ...