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Applied discrete event simulation for root cause analysis and evaluation of corrective process change Efficacy within vaccine manufacturing
(Massachusetts Institute of Technology, 2020)
Digital Transformation of the Biopharmaceutical industry is enabling improved operations through smart manufacturing. One area of interest is the application of advanced data analytics techniques to supplement traditional ...
Using discrete-event simulation to increase system capacity : a case study of an assembly plant
(Massachusetts Institute of Technology, 2020)
As part of its effort to introduce new technology and to improve the manufacturing system for the 777X production line, Boeing has made a significant capital investment in the Composite Wing Center (CWC). The new facility ...
Value of distribution-level reactive power for combined heat and power systems
(Massachusetts Institute of Technology, 2020)
As the U.S. electric grid continues to experience an increase in the penetration of distributed energy resources (DER), electric utilities are evaluating new approaches for utilizing DER to help cost-effectively maintain ...
Deploying the right technology : a framework for digital strategy and selection at the United States Postal Service to shape the future of work
(Massachusetts Institute of Technology, 2020)
With the rapid evolution of technology from more affordable hardware and data storage to artificial intelligence, companies must evolve their technology strategy to remain relevant. Federal agencies are no exception as ...
Optimizing inbound freight mode decisions
(Massachusetts Institute of Technology, 2020)
Retail manufacturers often expedite inbound freight shipments from contract manufacturing bases to their distribution centers in destination markets at high cost to improve service levels to their wholesale partners and ...
Artificial intelligence infrastructure into material attributes insights
(Massachusetts Institute of Technology, 2020)
The development of a biopharmaceutical manufacturing process involves an assessment of all possible sources of variation throughout each of the unit operations in the drive toward six sigma manufacturing. The primary goal ...
Evaluating modeling techniques for quantifying production risk in contact lens manufacturing
(Massachusetts Institute of Technology, 2020)
Johnson & Johnson Vision (JJV) is a leading manufacturer of contact lenses offering a variety of vision correction products. They have a strong commitment to innovation--defining new product categories and improving existing ...
Commercial technology transfer optimization for drug substance process development
(Massachusetts Institute of Technology, 2019)
Commercial technology transfer for biopharmaceuticals is the process of transferring process and product knowledge between process development and manufacturing organizations to achieve product realization. This process ...
System dynamics, market microstructure and asset pricing
(Massachusetts Institute of Technology, 2013)
Traditional asset pricing approaches are not able to explain extreme volatility and tail events that characterized financial markets in the past decade. System Dynamics theory, which is still underutilized in financial ...
Analysis and modeling of Spain's power sector in order to define the best incentive policies for achieving an optimum energy mix
(Massachusetts Institute of Technology, 2013)
The goal of this thesis is the development of a model of the Spanish energy mix in order to be able to forecast its evolution in function of exogenous variables such as the public opinion about specific technologies, the ...