Search
Now showing items 31-40 of 482
Contributions of aromatic pairs of human Gamma-D-Crystallin to its folding, stability, aggregation, and interaction with human Alpha B-Crystallin
(Massachusetts Institute of Technology, 2012)
Two distinct groups of proteins, a-crystallins and [Beta][gamma]-crystallins, constitute 90% of the vertebrate eye lens soluble proteins. Long-term solubility and stability against unfolding and aggregation are essential ...
Mnemonic information in the rodent hippocampus during wake and sleep states
(Massachusetts Institute of Technology, 2002)
To investigate the representation of information in the hippocampus during memory processes, we simultaneously monitored the spiking activity of many single neurons in freely behaving rats during spatial locomotor tasks ...
Phosphorus physiology of the marine cyanobacterium Trichodesmium
(Massachusetts Institute of Technology, 2010)
Primary producers play a critical role in the oceanic food chain and the global cycling of carbon. The marine diazotroph Trichodesmium is a major contributor to both primary production and nitrogen fixation in the tropical ...
Structural elucidation of a common architecture of the nuclear pore complex and COPIl vesicle coats
(Massachusetts Institute of Technology, 2010)
Nuclear pore complexes (NPCs) are massive protein assemblies that perforate the nuclear envelope and form the exclusive passageway for nucleocytoplasmic transport. NPCs play critical roles in molecular transport and a ...
Roles for chromatin regulators during differentiation of embryonic stem cells
(Massachusetts Institute of Technology, 2012)
Mammalian development involves the process by which a single fertilized egg develops into an adult with over 200 specialized cell types, each with a distinct gene expression pattern controlling its cellular state. As cells ...
The role of Huntingtin in fast axonal transport
(Massachusetts Institute of Technology, 2012)
Huntington's Disease (HD) is an autosomal dominant, neurodegenerative disease that occurs when an expansion of the polyQ tract of the huntingtin gene expands to greater than ~35 residues. This mutation leads to aggregation ...
Transport activity dependent regulation of the yeast general amino acid permease
(Massachusetts Institute of Technology, 2011)
The general amino acid permease Gap1p of Saccharomyces cerevisiae scavenges amino acids from the extracellular medium for use as nitrogen sources in starvation conditions. Because unlimited uptake of both naturally occurring ...
Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
(Massachusetts Institute of Technology, 2011)
Neuroanatomical bilateral asymmetry is a widespread feature in both vertebrates and invertebrates. Although mostly bilaterally symmetric, the nervous system of Caenorhabditis elegans displays bilateral asymmetry. Bilateral ...
Sequence of the mouse Y chromosome
(Massachusetts Institute of Technology, 2008)
The mouse Y chromosome has been studied for over 50 years, from the early sex determination and immunological phenotypes attributed to it in the 1950s, to the several mouse Y permatogenic phenotypes and the sex ratio ...
GP96 and the immune response
(Massachusetts Institute of Technology, 2001)