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Evaluating the impact of critical product quality attributes on patient outcomes in biologics
(Massachusetts Institute of Technology, 2019)
The primary goal of this project is to link critical product quality attributes in biological medicines with patient outcomes as evidenced by clinical trial data. This project adopts a novel methodology of applying statistical ...
Reducing inventory through supply chain coordination and improved lead times
(Massachusetts Institute of Technology, 2020)
In supply chain management, it is commonly held that reducing lead times and minimum order quantities (MOQs) from suppliers can drive down the customer's inventory levels substantially. Customers providing a consumption ...
Next generation commercial aircraft engine maintenance, repair, and overhaul capacity planning and gap analysis
(Massachusetts Institute of Technology, 2018)
A critical element in maintaining engine safety and in providing post-production service and support of a commercial aircraft engine is the complete worldwide network of maintenance, repair, and overhaul facilities. Matching ...
Demand forecasting for aircraft engine aftermarket
(Massachusetts Institute of Technology, 2008)
In 2006, Pratt and Whitney launched the Global Material Solutions business model aiming to supply spare parts to non-OEM engines with minimum 95% on-time delivery and fill-rate. Lacking essential technical knowledge of the ...
Inbound supply chain optimization with ship-mode variation in a fixed-capacity fulfillment center
(Massachusetts Institute of Technology, 2018)
each of the past two years. In order to scale with expected continued sales growth, Amazon has been investing heavily in its inbound supply chain, where product is received and allocated to various nodes, with cross-dock ...
Improving lead time setting and on-time delivery commitments under uncertain supply conditions
(Massachusetts Institute of Technology, 2018)
As Dell seeks to continually improve customer experience, the company is identifying new and innovative ways to improve on-time delivery. Inventory shortages that occur prior to production account for approximately 35% of ...
Six Sigma process improvements and sourcing strategies following factory fire
(Massachusetts Institute of Technology, 2005)
This thesis addresses Six Sigma process improvements and the supplier management issues resulting from the shift to external suppliers in the aftermath of a fire. Originally, this thesis was to address a lean implementation ...
Development of a tool for forecasting a warehouse facility footprint and enabling rapid scenario analysis
(Massachusetts Institute of Technology, 2010)
Companies in every industry, including both manufacturers and service providers, must make decisions about their operational footprint -the amount of building space required for business needs such as storing inventory and ...
Implementing change through a supplier evaluation process
(Massachusetts Institute of Technology, 2010)
With increased global competition, companies find that they must adjust and adapt to a supply chain model that incorporates more strategic suppliers. Pratt & Whitney, a division of United Technology Corporation, is no ...
Predicting corrosion on protected buried steel natural gas distribution pipelines
(Massachusetts Institute of Technology, 2015)
PG&E uses cathodic protection, which connects the pipeline to sacrificial anodes that corrode instead of the pipeline, to prevent corrosion on its buried steel natural gas pipelines. However, corrosion leaks still occur. ...