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Now showing items 31-40 of 423
Integrating additive manufacturing into operations at middle market companies
(Massachusetts Institute of Technology, 2019)
Ascent Aerospace's leadership recognizes the transformative potential of additive manufacturing (AM) to the aerospace tooling industry. As a middle market company, Ascent required a deliberate approach to identifying areas ...
Application of risk management frameworks to medical device production development
(Massachusetts Institute of Technology, 2019)
Effective risk management is critical when manufacturing medical products to avoid any potential impact to patients due to supply disruptions or quality excursions. As Flex LTD, an end-to-end manufacturing solutions provider, ...
Data-driven predictive modeling for cell line selection in biopharmaceutical production
(Massachusetts Institute of Technology, 2019)
A critical component of the biopharmaceutical development cycle is the selection of the cell line that will become the Master Cell Bank for product manufacturing for clinical and commercial use. This cell line selection ...
Manufacturing footprint strategy for product line expansion
(Massachusetts Institute of Technology, 2019)
To reach its long term revenue targets, EDSCO Fasteners must expand its smooth bar anchor bolt product line to increase revenue generation. In order to maximize profit during this expansion, an operational strategy must ...
Reverse logistics supply chain process modeling and simulation
(Massachusetts Institute of Technology, 2019)
As consumer preferences shift towards online shopping and utilizing their homes as fitting rooms, traditional brick and mortar retailers are faced with the challenge to adapt. Many retailers are experiencing a growing ...
An equipment selection methodology for continuous manufacturing of small-molecule drugs
(Massachusetts Institute of Technology, 2019)
Flexible, modular, continuous manufacturing small-scale plants (MCSPs) for small-molecule drugs have been recognized as potential safe and economical solutions for pharmaceutical manufacturing. However, among the variety ...
An analysis and mitigation of demand variability on external supply chains
(Massachusetts Institute of Technology, 2019)
In the pharmaceutical industry, increasing product complexity, shifts towards specialty medicine and growth in emerging markets have resulted in increased forecast variation and manufacturing complexity for new products. ...
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)
Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ...
Quantifying a fair labor value for garment production through prediction of factory efficiency
(Massachusetts Institute of Technology, 2019)
Li&Fung is a world leader in logistics, sourcing, and procurement; connecting manufacturing vendors with major retail brands. Recently, there has been an increasing consumer demand for more sustainably produced and sourced ...
Big data analysis interrogating raw material variability and the impact on process performance
(Massachusetts Institute of Technology, 2019)
Within the biopharmaceutical industry, material sciences is a rapidly growing field to continue to ensure reliable production and delivery of medicines. Consequently, there is an on-going need to evaluate and assess new ...