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Process for evaluating options for materials management outsourcing
(Massachusetts Institute of Technology, 2004)
This thesis investigates the issues involved with the outsourcing of the materials management function within aerospace assembly, proposing a process for determining whether all or part of the responsibility should be given ...
Lean supplier relationships in the United Kingdom .
(Massachusetts Institute of Technology, 2004)
The Eastman Kodak Company's Annesley, United Kingdom facility assembles consumer and professional film for distribution to the European, Middle Eastern, African, and Russian (EAMER) region. Under pressure from digital ...
Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
(Massachusetts Institute of Technology, 2011)
Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of ...
High reliability performance in Amgen Engineering
(Massachusetts Institute of Technology, 2012)
Amgen is in the midst of a transformative initiative to become operationally more efficient. For Amgen Engineering, this initiative has prompted a reevaluation of the entire organization and brought to light the need to ...
An equipment selection methodology for continuous manufacturing of small-molecule drugs
(Massachusetts Institute of Technology, 2019)
Flexible, modular, continuous manufacturing small-scale plants (MCSPs) for small-molecule drugs have been recognized as potential safe and economical solutions for pharmaceutical manufacturing. However, among the variety ...
Modeling and economic evaluation of early stage clinical monoclonal antibody manufacturing using single use technology
(Massachusetts Institute of Technology, 2015)
A critical cost driver in the product development process is the manufacturing of clinical trial material supplies. The clinical manufacturing process operates under similar regulatory burdens as commercial biopharmaceutical ...
Using value stream mapping to improve documentation processes in the biopharmacutical industry
(Massachusetts Institute of Technology, 2010)
This thesis describes how a 55% reduction in error rate and a 92% decrease in cycle-time were achieved in a batch production records process in a biotech manufacturing facility by utilization of value-stream mapping. The ...
A short-range forecasting and inventory strategy for new product launches
(Massachusetts Institute of Technology, 2005)
Companies like Procter & Gamble that operate on a make-to-stock strategy use forecasts to drive their manufacturing, selling, and buying processes. Because forecasting future demand is not an exact science, inventory ...
Overcoming organization barriers to adopting sustainable business practices
(Massachusetts Institute of Technology, 2010)
Companies of all sizes are now looking for ways to reduce their energy use and carbon emissions, motivated by the desire to save money, improve public relations, and prepare for a possible carbon tax. From a technical ...
Process Intensification of Spodoptera frugiperda (Sf) Cell Growth via Multi-Parallel Bioreactor System
(Massachusetts Institute of Technology, 2020)
The objective of this project is to improve the yield of the fed-batch manufacturing process for the production of Flublok influenza vaccine, which was approved by the FDA in 2018. In short, Spodoptera frugiperda (SF+) ...