Search
Now showing items 41-50 of 51
Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
(Massachusetts Institute of Technology, 2009)
Heightened competitive pressures, changes in the regulatory atmosphere, and dropping research and development productivity have been plaguing the pharmaceutical and biotechnology industries. Amgen has felt the effects of ...
Evaluating a continuous improvement initiative using Stakeholder Value Mapping
(Massachusetts Institute of Technology, 2006)
Lean implementations have had a mixed record of success in organizations. One possible explanation for this observation is that lean is built upon a value system that is not always shared by the organizations trying to ...
Strategic development of a manufacturing execution system (MES) for cold chain management using information product mapping
(Massachusetts Institute of Technology, 2011)
The Vaccines & Diagnostics (V&D) division of Novartis recently developed a global automation strategy that highlights the need to implement a manufacturing execution system (MES). Benefits of an MES (electronic production ...
Bioreactor Fill Process Control Using Inline Concentration Measurement
(Massachusetts Institute of Technology, 2014)
Some biopharmaceutical companies have responded to evolution of the competitive landscape by placing additional emphasis on reducing their costs of manufacturing as a means of maintaining competitiveness. The prototypical ...
Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment
(Massachusetts Institute of Technology, 2016)
Gene therapy is a promising modality for the potential treatment of rare Mendelian diseases. To date a number of high profile proof-of-concept studies within the industry have demonstrated the significant disease-correcting ...
Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
(Massachusetts Institute of Technology, 2013)
This thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a ...
Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
(Massachusetts Institute of Technology, 2011)
Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of ...
High reliability performance in Amgen Engineering
(Massachusetts Institute of Technology, 2012)
Amgen is in the midst of a transformative initiative to become operationally more efficient. For Amgen Engineering, this initiative has prompted a reevaluation of the entire organization and brought to light the need to ...
Development of operations based long range network capacity planning models
(Massachusetts Institute of Technology, 2011)
Planning for vaccines manufacturing capacity is both a complex task requiring many inputs and an important function of manufacturers to ensure the supply of vaccines that prevent life-threatening illnesses. This thesis ...
Forecasting resource requirements for drug development long range planning
(Massachusetts Institute of Technology, 2010)
This thesis investigates the use of a task-based Monte Carlo simulation model to forecast headcount and manufacturing capacity requirements for a drug development organization. A pharmaceutical drug development group is ...