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Momentum and scalar transport in vegetated shear flows
(Massachusetts Institute of Technology, 2005)
Environmental aquatic flows are seldom free of vegetative influence. However, the impact of submerged vegetation on the hydrodynamics and mixing processes in aquatic flows remains poorly understood. In this thesis, I present ...
A continuum theory with long-range forces for solids
(Massachusetts Institute of Technology, 2005)
A non-local integral-type continuum theory, introduced by Silling [61] as peridynamic theory, is analyzed. The theory differs from classical (local) continuum theories in that it involves long-range forces that act between ...
Command in air war : centralized vs. decentralized control of combat airpower
(Massachusetts Institute of Technology, 2005)
This study answers the question, "What has been the impact of the Information Age on the Air Force's doctrinal tenet of "centralized control and decentralized execution?" It traces the evolution of command and control of ...
Development of new parameters for structure determination and dynamic investigations on biomacromolecules by NMR
(Massachusetts Institute of Technology, 2005)
Nuclear magnetic resonance (NMR) spectroscopy is unique in the content of structural as well as dynamic information that it can provide at atomic resolution. The aim of this PhD-thesis was to contribute to the understanding ...
Mechanistic investigation of polyhydroxybutyrate (PHB) synthases and elucidation of PHB biosynthesis and degradation process in Wautersia eutropha H16
(Massachusetts Institute of Technology, 2005)
Polyhydroxyalkanoate (PHA) synthase from various bacterial organisms is able to catalyze the polymerization of (R)-hydroxyalkanoate-CoAs into high molecular weight PHAs under nutrient- limited conditions in the presence ...
The germline- and tissue-specific effects of endogenous point-mutant p53
(Massachusetts Institute of Technology, 2005)
p53 is frequently altered in human tumors through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of- function properties to p53. To ascertain the ...
Long-term activity-induced changes in the brain : a study of translational regulation and structural plasticity
(Massachusetts Institute of Technology, 2005)
Long-lasting changes must take place in the brain to store the skills and memories that have been learned by the organism throughout its history. Long-term memory (LTM), and its cellular correlate, the late-phase of long-term ...
Oligosaccharide-mediated targeting of dendritic cells and the development of carbohydrate microarrays
(Massachusetts Institute of Technology, 2005)
Bone-marrowed derived dendritic cells (DCs) constitute a critical arm of the immune system capable of polarizing the immune response toward active immunity or tolerance. Successful therapeutic modulation of DC function in ...
Critical thickness in silicone thermosets
(Massachusetts Institute of Technology, 2005)
Critical thickness effects are utilized to achieve high fracture toughness in brittle polymers. The postulate of critical thickness, which is: "Macroscopically brittle polymers deform in a ductile fashion below a critical ...
Two essays in commonality
(Massachusetts Institute of Technology, 2005)
In the first part of this thesis we consider a manufacturer that introduces successive generations of products, possibly on multiple similar production lines. We consider two types of production phase for this firm; pilot ...