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Modeling the effects of advanced automation and process design on Cell Line Development
(Massachusetts Institute of Technology, 2015)
Research and development of biologic drugs is a time- and resource-intensive process that can span several years and billions of dollars. Any improvements in the efficiency and end-to-end cycle time of this process provide ...
Modeling and economic evaluation of early stage clinical monoclonal antibody manufacturing using single use technology
(Massachusetts Institute of Technology, 2015)
A critical cost driver in the product development process is the manufacturing of clinical trial material supplies. The clinical manufacturing process operates under similar regulatory burdens as commercial biopharmaceutical ...
Cannibalization effects of products in Zara's stores and demand forecasting
(Massachusetts Institute of Technology, 2015)
Because of short product life cycles, large product offerings and fickle consumer tastes, product demand in the apparel retail industry is volatile and difficult to predict. It is also thought to be impacted significantly ...
A Framework for Analyzing Forecast Accuracy Metrics
(Massachusetts Institute of Technology, 2015)
Demand Planning forecasts at Nike, Inc. are used by many groups: Supply Planning/Materials Planning, Sourcing, Categories/Merchandising, Finance, S&OP, and Sales. These groups take forecasts as an input to make key decisions. ...
Analysis and productivity improvement of an automated material handling system through simulation
(Massachusetts Institute of Technology, 2015)
As Amazon.com has grown, the company has invested in warehouse systems similar to those traditionally found in manufacturing. These systems are a complex and interconnected set of manned work processing stations linked ...
Methods for predicting inventory levels in a segmented retail supply chain
(Massachusetts Institute of Technology, 2015)
Inventory is the largest asset on Nike's balance sheet-$3.9 Billion on May 3 1 st, 2014-and a key indicator of supply chain health. With new markets, products, and channels being added to Nike's sales portfolio each year, ...
Applying constraint-based theory to a complex aerospace manufacturing process
(Massachusetts Institute of Technology, 2015)
A new airplane model is quickly ramping up in production rates, and in order to achieve the organizational targets and commitments, Flow Days, Unit Hours and Cycle Times must be reduced throughout the entire supply chain. ...
Risk mitigation of pipeline assets through improved corrosion modeling
(Massachusetts Institute of Technology, 2015)
Infrastructure has to weather the elements and still function. Gas transmission and distribution piping at a utility are no exception. Atmospheric corrosion deteriorates the integrity of the natural gas system, and utilities ...
Analysis and implementation of laboratory automation system
(Massachusetts Institute of Technology, 2015)
Quest Diagnostics is a large company that analyzes millions of medical specimens every day using a variety of analytical equipment. It is implementing a fully automated line in a major laboratory. The automation line is ...
Exploring barriers, enablers,jJustification and planning methods for total productive maintenance implementation in automated production of commercial airplanes
(Massachusetts Institute of Technology, 2015)
The 737 program is currently producing 42 airplanes per month and will increase that production rate to 47 per month by 2017 and 52 per month in 2018 [1] [2]. In order to help meet these rates Boeing plans to increase the ...