Search
Now showing items 1-5 of 5
Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics
(Massachusetts Institute of Technology, 2005)
The purpose of this thesis is to explore the conjugation of biomolecules to platinum(IV) compounds. Ever since the serendipitous discovery that cisplatin has cytotoxic properties in the 1970's, research has focused on both ...
Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
(Massachusetts Institute of Technology, 2005)
The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This ...
Inhibition of Hsp90 in Streptomyces coelicolor
(Massachusetts Institute of Technology, 2005)
Inhibition of the chaperone protein Hsp90 in plants and insects has been found to result in drastic changes in phenotype. We investigated the effect of Hsp90 inhibition on the bacteria Streptomyces coelicolor. These changes ...
Design and synthesis of novel functionalized sensors for the biological imaging of zinc(II) and nitric oxide
(Massachusetts Institute of Technology, 2005)
CHAPTER 1: Fluorescent Sensors for the Biological sensing of Zinc(II) A variety of fluorescent techniques have been developed for the in vivo sensing of Zn2+. This chapter presents a brief overview of techniques used to ...
Synthesis, structure and spectroscopic investigations of luminescent heterobimetallic gold(I)-Rhodium(I) species
(Massachusetts Institute of Technology, 2005)
A novel, three-coordinate gold(I) dimer, Au2(tfepm)3Cl2 (la, lb), was synthesized and structurally characterized. Four gold(I)-rhodium(I) heterobimetallic complexes, AuIRh'(tBuNC)2(-dppm)2C12 (2), Au'Rh'(tBuNC)2(u-dmpm)2Cl2 ...