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The DNA of a high-performing manufacturing organization : improving operations capability through performance measurement
(Massachusetts Institute of Technology, 2006)
The Broad Institute of MIT, Harvard, and the Whitehead Institute, contains the world's highest-throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project ...
A framework for analyzing biopharmaceutical product introduction in an emerging market
(Massachusetts Institute of Technology, 2006)
Biopharmaceutical companies are under constant pressure to deliver double-digit growth. In traditional markets such as the U.S., Japan, and the European Union growth is stagnant, and profit margins are falling due to ...
Batch sizing strategy & production load leveling in a multi-step chemical manufacturing process
(Massachusetts Institute of Technology, 2005)
In the last couple of years Eastman Kodak Company went through major changes in its strategic direction. The same disruptive technologies that they helped develop for digital imaging have shaped a new industry, and the ...
Analyzing and improving throughput of Automated Storage and Retrieval Systems in personal computer manufacturing
(Massachusetts Institute of Technology, 2005)
The content of this thesis draws heavily on work completed during a 6.5 month MIT Leaders for Manufacturing (LFM) internship at Dell Corporation's personal computer manufacturing facility in Lebanon, Tennessee (EG1) from ...
Information management using Web 2.0 technology
(Massachusetts Institute of Technology, 2009)
Web 2.0, the ultimate platform for tacit based knowledge work has finally arrived. User driven, collaborative platform based tools including wikis, web mash-ups, discussion boards, linkage based search engines, and tagging ...
Fuel cells : manufacturing strategy for emerging technologies
(Massachusetts Institute of Technology, 2001)
Firms attempting to commercialize emerging technologies face unique challenges. Strategy making is one of the major challenges especially when the industry structure is embryonic. In this environment, it is important not ...
Achieving business and operational excellence in the pharmaceutical industry
(Massachusetts Institute of Technology, 2008)
Historically the pharmaceutical industry has been highly profitable. However, the increasing regulatory requirements, bargaining power of buyers, and drug failures together with the threat of biosimilars and decreasing R&D ...
Operational streamlining in a high-throughput genome sequencing center
(Massachusetts Institute of Technology, 2006)
Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...
Evaluating a continuous improvement initiative using Stakeholder Value Mapping
(Massachusetts Institute of Technology, 2006)
Lean implementations have had a mixed record of success in organizations. One possible explanation for this observation is that lean is built upon a value system that is not always shared by the organizations trying to ...
The conclusion of a biologic's lifecycle : manufacturing sourcing strategies on the eve of follow-on biologics
(Massachusetts Institute of Technology, 2008)
The Amgen Rhode Island facility is dedicated to the production of the biological bulk drug substance (BDS) for Enbrel® (etanercept), which blocks the action of one's immune system, helping to treat immune diseases, such ...