Search
Now showing items 1-10 of 46
Capacity analysis, cycle time optimization, and supply chain strategy in multi-product biopharmaceutical manufacturing operations
(Massachusetts Institute of Technology, 2011)
Application of system optimization theory, supply chain principles, and capacity modeling are increasingly valuable tools for use in pharmaceutical manufacturing facilities. The dynamics of the pharmaceutical industry - ...
Assessing and reducing product portfolio complexity in the pharmaceutical industry
(Massachusetts Institute of Technology, 2011)
Overly complex product portfolios lead to inefficient use of resources and limit an organization's ability to react quickly to changing market dynamics. The challenges of reducing portfolio complexity are defining excess ...
Developing global inventory and resupply forecasting policies for the vaccines industry
(Massachusetts Institute of Technology, 2011)
Appropriate inventory management is important for many businesses throughout the world. For the vaccines industry, appropriate inventory policies impact both the business' profitability and people's lives. An optimal policy ...
Process management applications in biopharmaceutical drug production
(Massachusetts Institute of Technology, 2011)
Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...
Managing variability to improve quality, capacity and cost in the perioperative process at Massachusetts General Hospital
(Massachusetts Institute of Technology, 2011)
The widely held assumption is that to improve access and quality of health care, we need to spend more. In fact, that is not necessarily true. The results of this project, performed at Massachusetts General Hospital (MGH), ...
Forward thinking in reverse : design, implementation, and continuous monitoring of a closed-loop supply chain using optimization, simulation, and dashboard systems to maximize net recovery
(Massachusetts Institute of Technology, 2011)
Developed during our recent six-month engagement at Dell-a leading computer manufacturer and services provider with one of the world's leading supply chains--we discuss a network flow-based mixed-integer linear program ...
M28 Fixed wing transport aircraft cost reduction
(Massachusetts Institute of Technology, 2011)
The M28 is a Polish short-takeoff-and-landing (STOL) light cargo aircraft developed in 1984 and currently built by PZL Mielec, a subsidiary of United Technology Corporation (UTC). There has been renewed interest in the ...
Lean transformation and relocation of jet engine assembly operations
(Massachusetts Institute of Technology, 2011)
As part of continuing lean transformation efforts at Pratt & Whitney, the Middletown Engine Center has turned its focus on the GP7000 turbofan engine as a target for lean implementation. Projected increases in GP7000 ...
Optimization of shake inspections
(Massachusetts Institute of Technology, 2011)
The Boeing 737 program has recently announced an increase in the production rate from 31.5 airplanes per month to 35 airplanes per month. Throughout the production value stream, opportunities to improve quality and reduce ...
Corporate sustainability assessment methodology
(Massachusetts Institute of Technology, 2011)
Sustainability is a vague concept specifically in the context of a corporate world. There are numerous definitions for corporate sustainability and just as many ways of evaluating it. This work attempts to define, structure ...