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Reducing reagent waste through process improvement and preventive maintenance
(Massachusetts Institute of Technology, 2017)
Quest Diagnostics has committed to reducing operating expenses by $1.3B between 2012 and 2017. A portion of the cost-saving initiative focuses on reagents - expensive liquids that are combined with patient samples to detect ...
Establish methodology for estimating process performance capability during the design phase for biopharmaceutical processes
(Massachusetts Institute of Technology, 2016)
It is highly desirable to apply a systematic methodology in order to measure, improve and ensure robust process performance during process development (PD) for biopharmaceutical processes. Designing a standardized approach ...
Modeling end-to-end order cycle-time variability to improve on-time delivery commitments and drive future state metrics
(Massachusetts Institute of Technology, 2016)
Dell is accelerating investments to simplify and improve one of the core competencies it was founded on, customer experience. One goal within this initiative is to increase the percentage of orders that are ontime to a ...
Integrated supply and production network design
(Massachusetts Institute of Technology, 2016)
As Company X looks to improve customer service and deliver new growth opportunities, it is driving toward a more efficient, aligned and effective organization that eliminates waste through integration of its supply and ...
Analysis of outbound process defects at Amazon's ONT2 Fulfillment Center
(Massachusetts Institute of Technology, 2016)
This thesis investigated two outbound process defects that result in damaged, late, missing or wrong-item shipments, leading to a poor customer experience and concessions for Amazon. Reducing these defects will improve ...
Strategic analysis of technical, commercial, and regulatory influences on the commercialization of hydrogen fuel cell vehicles
(Massachusetts Institute of Technology, 2016)
Increasing regulatory pressures are being applied to automotive manufacturers requiring them to reduce the negative impacts that their vehicles have on the environment. In response to these regulations, and evolving consumer ...
Applying factory physics to manual assembly at an aerospace fabrication site
(Massachusetts Institute of Technology, 2017)
The assembly of welded reservoirs at the Boeing Tube Duct, and Reservoir Center (TDRC) is a traditional batch and queue operation that relies heavily on manual craftsmanship. The production system experiences high variability ...
Optimizing large-volume scheduling for cost avoidance
(Massachusetts Institute of Technology, 2016)
This dissertation presents the results of developing optimization algorithms for use in operational scheduling of airplane stalls and paint hangars at the Boeing Company's Everett Delivery Center. With the increasing number ...
Electric utility storm restoration : crew work allocation optimization
(Massachusetts Institute of Technology, 2016)
Storms damage Atlantic Electric's electric distribution network, resulting in power outages and expensive repairs. After severe storms Atlantic Electric hires external contractor crews to perform the majority of the ...
Assessing the impact of container marking implementation
(Massachusetts Institute of Technology, 2016)
Amgen is implementing new capabilities across the Amgen manufacturing network in order to code containers at the unit-level to reduce the possibility of mix-ups of unlabeled drug products. In order to prepare for the ...