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Development of an inertial generator for embedded applications in rotating environments
(Massachusetts Institute of Technology, 2007)
Inertial generators are devices that generate electrical energy from their inertial motion, and have only one mechanical connection with their surroundings. This makes them suitable power sources for embedded systems ...
Does early success and market dominance help or hinder future innovative capability?
(Massachusetts Institute of Technology, 2007)
Many successful innovative companies are acquired and become absorbed into larger more structured organizations. The innovation capabilities of the company change in the new environment depending on the extent to which ...
0 + 0 = 1 : the appliance model of selling software bundled with hardware
(Massachusetts Institute of Technology, 2007)
The business model of selling software bundled with hardware is called the appliance model. As hardware becomes less and less expensive and open source software is being offered for free, the traditional business model of ...
Nitrene transfer reactions by late transition metal complexes
(Massachusetts Institute of Technology, 2007)
This thesis presents nitrene transfer reactions that are catalyzed or mediated by late transition metal complexes. Sterically large, fluorinated supporting ligands are used to minimize potential side reactions. A new ...
Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways
(Massachusetts Institute of Technology, 2007)
Protein phosphorylation is a central regulatory mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are ...
Synthesis and solution state self-assembly of linear-dendritic block copolymers
(Massachusetts Institute of Technology, 2007)
Linear-dendritic block copolymers consisting of a poly(styrene) linear block and poly(amidoamine) dendrimer block were synthesized and examined for their ability to self-assemble in both aqueous environments and organic/aqueous ...
Quantum chemistry for spectroscopy : a tale of three spins (S = 0, 1/2, and 1)
(Massachusetts Institute of Technology, 2007)
Three special topics in the field of molecular spectroscopy are investigated using a variety of computational techniques. First, large-amplitude vibrational motions on ground-state singlet (S0) potential energy surfaces ...
[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines
(Massachusetts Institute of Technology, 2007)
Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts ...
Novel function and regulation of mutagenic DNA polymerases in Escherichia coli
(Massachusetts Institute of Technology, 2007)
The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV-light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
Effects of water on chemomechanical instabilities in amorphous silica : nanoscale experiments and molecular simulation
(Massachusetts Institute of Technology, 2007)
We elucidate the tensile failure mechanism of amorphous silica and the effects of water on the process, combining: (a) atomic force microscope (AFM) bending tests, (b) molecular dynamics (MD) simulation and (c) molecular ...