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Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
(Massachusetts Institute of Technology, 2008)
The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...
Emerin and inherited disease
(Massachusetts Institute of Technology, 2004)
(cont.) nucleus and at the nuclear surface.
A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy
(Massachusetts Institute of Technology, 2009)
Diseases affecting the retina, such as Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP), result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is ...
Characterization of human expired breath by solid phase microextraction and analysis using gas chromatography-mass spectrometry and differential mobility spectrometry
(Massachusetts Institute of Technology, 2005)
Breath analysis has potential to become a new medical diagnostic modality. In this thesis, a method for the analysis of human expired breath was developed using gas chromatography-mass spectroscopy. It was subsequently ...
Septic shock : providing early warnings through multivariate logistic regression models
(Massachusetts Institute of Technology, 2007)
(cont.) The EWS models were then tested in a forward, casual manner on a random cohort of 500 ICU patients to mimic the patients' stay in the unit. The model with the highest performance achieved a sensitivity of 0.85 and ...
Influence of mitochondrial membrane potential on the cryopreservation survival of hepatocytes
(Massachusetts Institute of Technology, 2005)
Hepatocytes are widely used in the pharmaceutical and medical fields for drug metabolism studies, bioartificial liver devices, and repopulation of damaged livers as an alternative to transplantation. However, these cells ...
Image guidance in cardiac electrophysiology
(Massachusetts Institute of Technology, 2006)
Cardiac arrhythmias are characterized by a disruption or abnormal conduction of electrical signals within the heart. Treatment of arrhythmias has dramatically evolved over the past half-century, and today, minimally-invasive ...
Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix
(Massachusetts Institute of Technology, 2004)
The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed ...
A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation
(Massachusetts Institute of Technology, 2008)
Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To ...