Search
Now showing items 1-10 of 24
Assessing and reducing product portfolio complexity in the pharmaceutical industry
(Massachusetts Institute of Technology, 2011)
Overly complex product portfolios lead to inefficient use of resources and limit an organization's ability to react quickly to changing market dynamics. The challenges of reducing portfolio complexity are defining excess ...
Process management applications in biopharmaceutical drug production
(Massachusetts Institute of Technology, 2011)
Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...
Managing variability to improve quality, capacity and cost in the perioperative process at Massachusetts General Hospital
(Massachusetts Institute of Technology, 2011)
The widely held assumption is that to improve access and quality of health care, we need to spend more. In fact, that is not necessarily true. The results of this project, performed at Massachusetts General Hospital (MGH), ...
M28 Fixed wing transport aircraft cost reduction
(Massachusetts Institute of Technology, 2011)
The M28 is a Polish short-takeoff-and-landing (STOL) light cargo aircraft developed in 1984 and currently built by PZL Mielec, a subsidiary of United Technology Corporation (UTC). There has been renewed interest in the ...
Accelerating the development of complex products in extended enterprises
(Massachusetts Institute of Technology, 2011)
This thesis examines strategies to accelerate product development in a large commercial aerospace program structured as an extended enterprise where first and second tier suppliers perform most of the detailed product ...
Performance measurement system design for supply chain organizations
(Massachusetts Institute of Technology, 2011)
This thesis proposes a methodology to create an effective performance measurement system for an interconnected organization. The performance measurement system is composed of three components: a metrics set, a metrics ...
Improving supply chain responsiveness for diesel engine remanufacturing
(Massachusetts Institute of Technology, 2011)
Achieving a significant reduction in order-to-shipment lead-time of remanufactured diesel engines can dramatically decrease the amount of finished goods inventory that Caterpillar needs to carry in order to meet its delivery ...
Long range planning of biologics process development and clinical trial material supply process
(Massachusetts Institute of Technology, 2011)
This thesis investigates the feasibility of using a complex model with a Monte Carlo simulation model to forecast the financial, personnel, and manufacturing capacity resources needed for biologic drug development. Accurate ...
Allocation strategy for production network designed to mitigate risk
(Massachusetts Institute of Technology, 2011)
Amgen Inc. currently manufactures, formulates and fills substantially all of their global drug product units in a single primary facility ("Site 1A"). Concerned about the inherent risks posed by the geographic concentration ...
Value stream financial modeling for improved production decision making
(Massachusetts Institute of Technology, 2011)
Understanding the overall impact of a decision in a manufacturing system can be challenging given the complex production and financial structures in today's companies. While knowing the direct result of a local change may ...