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Roles of grain boundaries in cleavage cracking and thermal crack arrest experiments in iron-silicon alloy
(Massachusetts Institute of Technology, 2002)
High-angle grain boundaries in steel offer an important resistance to the propagation of cleavage cracks that affects the fracture toughness and can modulate the ductile-to-brittle transition temperature of fracture downward. ...
Finite element analysis of shells with layers
(Massachusetts Institute of Technology, 2002)
It is well established that thin shell structures frequently feature narrow bands of strain concentration and localized displacement irregularities referred to as boundary and internal layers. It is crucial to capture these ...
Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering
(Massachusetts Institute of Technology, 2007)
Defects in articular cartilage exhibit little spontaneous healing response, in part due to the limited number of chondrocytes available to infiltrate the defect and the absence of a provisional fibrin scaffold to accommodate ...
The development of a proff of principle superfluid Joule-Thomson refrigerator for cooling below 1 Kelvin
(Massachusetts Institute of Technology, 2005)
A new type of sub-Kelvin refrigerator, the superfluid Joule-Thomson refrigerator, has been developed and its performance has been experimentally verified. This refrigerator uses a liquid superfluid mixture of He and 4He ...
Structure and formation of β-sheet fibers
(Massachusetts Institute of Technology, 2003)
The spontaneous organization of protein monomers into fibers, bundles and networks is central to biology. Inspired by the repetitive patterns found in the amino acid sequence of natural fibrous proteins, short peptides ...
Centrifugal casting and fast curing of polydimethylsiloxane (PDMS) for the manufacture of micro and nano featured components
(Massachusetts Institute of Technology, 2009)
The thermosetting resin polydimethylsiloxane (PDMS) is commonly used to prototype micro and nano featured components. In the field of microfluidics, PDMS-based devices have been used for cell sorting, cell culturing, ...
Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications
(Massachusetts Institute of Technology, 2009)
The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...
Experimental and computational study of soot formation under diesel engine conditions
(Massachusetts Institute of Technology, 2004)
Past research has shown that during diesel combustion, soot is formed in local premixed fuel-rich regions. This project focuses on the fundamentals soot formation under fuel-rich conditions similar to those in diesel engine ...
A-Posteriori bounds on linear functionals of coercive 2nd order PDEs using discontinuous Galerkin methods
(Massachusetts Institute of Technology, 2006)
In this thesis, we extend current capabilities in producing error bounds on the exact linear functionals of linear partial differential equations in a number of ways. Unlike previous approaches, we base our method on the ...
Inverse Monte Carlo simulation of biomolecular conformation and coarse-grained molecular modeling of chondroitin sulfate conformation, titration, and osmotic pressure
(Massachusetts Institute of Technology, 2004)
The first part of this thesis is concerned with the solution structure determination problem. Whereas many biomacromolecules, such as proteins, can be adequately characterized by a single conformation in solution, numerous ...