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Predictive analysis of installation and operational qualification issues vs. process severity events
(Massachusetts Institute of Technology, 2020)
As the retail industry grows more popular, ABCD, a world-class electronic commerce (e-commerce) business, is increasingly building new Fulfillment Centers (FCs) to support this rapid demand growth. It is integral for ABCD ...
Commercial technology transfer optimization for drug substance process development
(Massachusetts Institute of Technology, 2019)
Commercial technology transfer for biopharmaceuticals is the process of transferring process and product knowledge between process development and manufacturing organizations to achieve product realization. This process ...
Improving project timelines using Al / ML to detect forecasting errors
(Massachusetts Institute of Technology, 2019)
This project focuses on the creation of a novel tool to detect and flag potential errors within Amgen's capacity management forecast data, in an automated manner using statistical analysis, artificial intelligence and ...
Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
(Massachusetts Institute of Technology, 2020)
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture ...
Business case assessment of unmanned systems level of autonomy
(Massachusetts Institute of Technology, 2012)
The federal government has continually increased its spending on unmanned aerial vehicles (UAVs) during the past decade. Efforts to drive down UAV costs have primarily focused on the physical characteristics of the UAV, ...
Quantifying the impact of care team discontinuities on medically unnecessary delays in inpatient flow
(Massachusetts Institute of Technology, 2016)
This thesis quantifies the impact of clinical care team discontinuities on inpatient length-of-stay (LOS) and admission wait time within Massachusetts General Hospital's Department of Medicine (DOM). The DOM is the hospital's ...
Routine Post-Procedure Recovery (RPPR) patients at Massachusetts General Hospital
(Massachusetts Institute of Technology, 2016)
This project offers improved strategies for managing the flow of surgical patients who are categorized as Routine Post-Procedure Recovery (RPPR) in Massachusetts General Hospital (MGH). Strategies were developed by analyzing ...
Stealth dicing characterization, optimization, integration, and operations management for ultra-thin stacked memory dies
(Massachusetts Institute of Technology, 2014)
This dissertation presents original work in the development of multi-strata subsurface infrared (1.342 [mu]m) nanosecond pulsed laser die singulation (stealth dicing) to enable defect-free ultra-thin stacked memory dies. ...
A framework For decision automation in operations
(Massachusetts Institute of Technology, 2017)
Amazon's leadership has set a goal to achieve a highly automated warehouse by 2020. Automation involves two challenges, physical movement and decision-making. Decision making often increase variability, defects and consumes ...
Modeling neuroscience patient flow and inpatient bed management
(Massachusetts Institute of Technology, 2014)
Massachusetts General Hospital (MGH) experiences consistently high demand for its more than 900 inpatient beds. On an average weekday, the hospital admits about 220 patients, with the emergency department (ED) and the ...