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Application of process analysis and optimization tools in hit-to-lead and lead optimization phases of drug discovery at EPP, NIBR
(Massachusetts Institute of Technology, 2010)
Given that research is based on innovation, it has been believed that its activities can only be optimized with equipment upgrade, increment in personnel scientific knowledge, development of new analytical software and/or ...
Using design of experiments to improve a batch chemical process
(Massachusetts Institute of Technology, 2010)
Novartis Vaccines and Diagnostics has made a strong commitment to manufacturing seasonal influenza vaccines through their cell culture technology called Optaflu®. The goal of this project is to improve overall process yield ...
The business case for continuous manufacturing of pharmaceuticals
(Massachusetts Institute of Technology, 2010)
Manufacturing in the pharmaceutical industry is presently characterized as a batch production system, which has existed in its current form for decades. This structure is the result of historical regulatory policy as well ...
Using value stream mapping to improve documentation processes in the biopharmacutical industry
(Massachusetts Institute of Technology, 2010)
This thesis describes how a 55% reduction in error rate and a 92% decrease in cycle-time were achieved in a batch production records process in a biotech manufacturing facility by utilization of value-stream mapping. The ...
Forecasting resource requirements for drug development long range planning
(Massachusetts Institute of Technology, 2010)
This thesis investigates the use of a task-based Monte Carlo simulation model to forecast headcount and manufacturing capacity requirements for a drug development organization. A pharmaceutical drug development group is ...
Overcoming organization barriers to adopting sustainable business practices
(Massachusetts Institute of Technology, 2010)
Companies of all sizes are now looking for ways to reduce their energy use and carbon emissions, motivated by the desire to save money, improve public relations, and prepare for a possible carbon tax. From a technical ...